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CUL1:FBXW11:SKP1 [cytosol]
Stable Identifier
R-CFA-1168592
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
CUL1:FBXW11:SKP1 [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CUL1 [cytosol]
(Canis familiaris)
FBXW11 [cytosol]
(Canis familiaris)
SKP1 [cytosol]
(Canis familiaris)
Participates
as an output of
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA (Canis familiaris)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 (Canis familiaris)
as an input of
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB (Canis familiaris)
Phosphorylated BORA binds SCF-beta-TrCp1/2 (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 (Canis familiaris)
as a component of
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
p-S252,S497,T501-BORA:SCF-beta-TrCp1/2 [cytosol] (Canis familiaris)
Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] (Canis familiaris)
SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol] (Canis familiaris)
Inferred From
SCF-beta-TRCP [cytosol]
(Homo sapiens)
(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
(Homo sapiens)
CUL1:FBXW11:SKP1 [cytosol]
(Homo sapiens)
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