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Me2K5-HIST2H3A [nucleoplasm]
Stable Identifier
R-CFA-1214225
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
J9P7X1
Locations in the PathwayBrowser
Expand all
Chromatin organization (Canis familiaris)
Chromatin modifying enzymes (Canis familiaris)
HDMs demethylate histones (Canis familiaris)
KDM1A, KDM1B demethylate Me2K5-histone H3 (Canis familiaris)
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
KDM5A-D demethylate Me2K5-histone H3 (Canis familiaris)
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
KDM5A-D demethylate Me3K5-histone H3 (Canis familiaris)
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
PKMTs methylate histone lysines (Canis familiaris)
Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4) (Canis familiaris)
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX1 (Canis familiaris)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Estrogen-dependent gene expression (Canis familiaris)
FOXA1 and GATA3 bind to CCND1 promoter (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm] (Canis familiaris)
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Me2K5-HIST2H3A [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:J9P7X1
Reference Genes
ENSEMBL:ENSCAFG00000024443
Participates
as a candidate of
Me2K5-histone H3 [nucleoplasm] (Canis familiaris)
as a member of
Histone H3 (H3K4me2) [nucleoplasm] (Canis familiaris)
Other forms of this molecule
2xAcK-HIST2H3A [nucleoplasm]
Me2aR27-HIST2H3A [nucleoplasm]
Me2aR18-HIST2H3A [nucleoplasm]
Me2sR9-HIST2H3A [nucleoplasm]
Me2sR3-HIST2H3A [nucleoplasm]
phospho-AcK9,14-p-S10-HIST2H3A [nucleoplasm]
phospho-AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
phospho-AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
phospho-AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
phospho-AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
phospho-AcK14,18-p-S10-HIST2H3A [nucleoplasm]
phospho-AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
phospho-AcK14,18-p-T11-HIST2H3A [nucleoplasm]
phospho-AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
Me2K28-HIST2H3A [nucleoplasm]
MeK37-HIST2H3A [nucleoplasm]
MeK80-HIST2H3A [nucleoplasm]
Me3K80-HIST2H3A [nucleoplasm]
Me2K80-HIST2H3A [nucleoplasm]
Me3K37-HIST2H3A [nucleoplasm]
Me2K37-HIST2H3A [nucleoplasm]
MeK-HIST2H3A [nucleoplasm]
MeK28-HIST2H3A [nucleoplasm]
MeK10-HIST2H3A [cytosol]
HIST2H3A [cytosol]
HIST2H3A [nucleoplasm]
Me3K28-HIST2H3A [nucleoplasm]
Me3K5-HIST2H3A [nucleoplasm]
Me2K5,Me2aR3-HIST2H3A [nucleoplasm]
Me2K10-HIST2H3A [nucleoplasm]
Ack10-HIST2H3A [nucleoplasm]
Me3K10-HIST2H3A [nucleoplasm]
phospho-p-T12, Me3K-10-HIST2H3A [nucleoplasm]
phospho-p-T12, Me2K-10-HIST2H3A [nucleoplasm]
phospho-p-T12,MeK-HIST2H3A [nucleoplasm]
phospho-p-T12-HIST2H3A [nucleoplasm]
AcK5-HIST2H3A [nucleoplasm]
AcK19-HIST2H3A [nucleoplasm]
Ack15-HIST2H3A [nucleoplasm]
AcK24-HIST2H3A [nucleoplasm]
MeR9-HIST2H3A [nucleoplasm]
MeR27-HIST2H3A [nucleoplasm]
MeR3-HIST2H3A [nucleoplasm]
MeR18-HIST2H3A [nucleoplasm]
Cit18-HIST2H3A [nucleoplasm]
Cit9-HIST2H3A [nucleoplasm]
Cit27-HIST2H3A [nucleoplasm]
MeK5-HIST2H3A [nucleoplasm]
Me2aR3-HIST2H3A [nucleoplasm]
Inferred From
Me2K5-HIST2H3A [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
N6,N6-dimethyl-L-lysine at 5 (in Homo sapiens)
Coordinate
5
PsiMod Name
N6,N6-dimethyl-L-lysine [MOD:00084]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine.
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