Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MAD2L1 [cytosol]
Stable Identifier
R-CFA-141400
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
MAD2L1, A0A8I3P814
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
Mitotic Spindle Checkpoint (Canis familiaris)
Amplification of signal from the kinetochores (Canis familiaris)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MAD2 converted to an inhibitory state via interaction with Mad1 (Canis familiaris)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1 binds kinetochore (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Release of activated MAD2 from kinetochores (Canis familiaris)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mad1:kinetochore complex [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
Inactivation of APC/C via CDC20 sequestration (Canis familiaris)
MAD2*CDC20 complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
Binding of the MCC complex to the APC/C complex (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Formation of the MCC complex (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Separation of sister chromatids (Canis familiaris)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mitotic Prometaphase (Canis familiaris)
EML4 and NUDC in mitotic spindle formation (Canis familiaris)
EML4 recruits NUDC to mitotic spindle (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore capture of astral microtubules (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Resolution of Sister Chromatid Cohesion (Canis familiaris)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore assembly (Canis familiaris)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
APC-Cdc20 mediated degradation of Nek2A (Canis familiaris)
Association of Nek2A with MCC:APC/C (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Degradation of multiubiquitinated Nek2A (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Multiubiquitination of Nek2A (Canis familiaris)
Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Association of Cyclin A with the APC/C (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Regulation of APC/C activators between G1/S and early anaphase (Canis familiaris)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
Inactivation of APC/C via CDC20 sequestration (Canis familiaris)
MAD2*CDC20 complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
Binding of the MCC complex to the APC/C complex (Canis familiaris)
MCC:APC/C complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Formation of the MCC complex (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate Formins (Canis familiaris)
AURKB phosphorylates DIAPH2-2 at kinetochores (Canis familiaris)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
Microtubule-bound kinetochore [cytosol] (Canis familiaris)
Kinetochore [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P814
Gene Names
MAD2L1
Reference Genes
BioGPS Gene:119864289 MAD2L1
ENSEMBL:ENSCAFG00845018701.1
Monarch:119864289 MAD2L1
NCBI Gene:119864289 MAD2L1
UCSC:A0A8I3P814 MAD2L1
Reference Transcript
RefSeq:XM_038564453.1 MAD2L1
RefSeq:XM_038425496.1 MAD2L1
RefSeq:XM_533278.5 MAD2L1
Other Identifiers
119864289
Cfa.1844.1.S1_at
CfaAffx.25205.1.S1_s_at
CfaAffx.7212.1.S1_s_at
GO:0000776
GO:0005634
GO:0043226
GO:0051301
GO:0051783
GO:1901991
GO:1990728
Participates
as an input of
Inactivation of APC/C via CDC20 sequestration (Canis familiaris)
Formation of the MCC complex (Canis familiaris)
MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
as a component of
MAD2*CDC20 complex [cytosol] (Canis familiaris)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Canis familiaris)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
Mitotic checkpoint complex [cytosol] (Canis familiaris)
as an output of
Release of activated MAD2 from kinetochores (Canis familiaris)
Inferred From
Activated MAD2L1 [cytosol]
(Homo sapiens)
MAD2L1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_038281424.1
,
XP_533278.2
,
XP_038420381.1
ENSEMBL
ENSCAFT00845033047
,
ENSCAFP00845025866
,
ENSCAFG00845018701
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
