Reactome | RBM8A [cytosol]

RBM8A [cytosol]

Stable Identifier

R-CFA-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RBM8A, A0A8I3NI72

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)
- Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
  - Transport of Mature Transcript to Cytoplasm (Canis familiaris)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Canis familiaris)
      - Transport of the export-competent mRNP complex through the NPC (Canis familiaris)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Canis familiaris)
        
        EJC [cytosol] (Canis familiaris)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Canis familiaris)
        
        Magoh-Y14 complex [cytosol] (Canis familiaris)
        
        RBM8A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NI72

Gene Names

RBM8A

Reference Genes

BioGPS Gene:475827 RBM8A

ENSEMBL:ENSCAFG00845011260.1

KEGG:cfa:475827 RBM8A

Monarch:475827 RBM8A

NCBI Gene:475827 RBM8A

UCSC:A0A8I3NI72 RBM8A

Reference Transcript

RefSeq:XM_005630728.2 RBM8A

Other Identifiers

475827

CfaAffx.17487.1.S1_s_at

GO:0000184

GO:0000381

GO:0000398

GO:0003723

GO:0003729

GO:0005634

GO:0005681

GO:0005737

GO:0006396

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0035145

GO:0043226

GO:0050684

GO:0051028

GO:0071006

GO:0071013

GO:1990501

GO:2000622

Participates

as a component of

Magoh-Y14 complex [cytosol] (Canis familiaris)

Other forms of this molecule

RBM8A [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845015653, ENSCAFT00845019982, ENSCAFG00845011260

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