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PTPN11 [cytosol]
Stable Identifier
R-CFA-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3PMT9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
PECAM1 interactions (Canis familiaris)
Interaction of PECAM-1 and SHP-2 (Canis familiaris)
PECAM-1:SHP-2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Interaction of Tie2 and Shp2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
pTie2 and SHP2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
G6B binds PTPN6,PTPN11 (Canis familiaris)
G6B:PTPN6,PTPN11 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SYK autophosphorylates (Canis familiaris)
G6B:PTPN6,PTPN11 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
p-Y7-CLEC1B dimer:PDPN binds SYK (Canis familiaris)
G6B:PTPN6,PTPN11 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Platelet homeostasis (Canis familiaris)
Platelet sensitization by LDL (Canis familiaris)
Interaction of PECAM-1 and SHP-2 (Canis familiaris)
PECAM-1:SHP-2 complex [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CTLA4 inhibitory signaling (Canis familiaris)
SHP2 phosphatase binds CTLA-4 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PD-1 signaling (Canis familiaris)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP-1 and SHP-2 bind pBTLA (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-20 family signaling (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
SHP1 and SHP2 bind the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN6,PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Interleukin-6 family signaling (Canis familiaris)
Interleukin-6 signaling (Canis familiaris)
PTPN11 binds CBL (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 binds p-Y759-IL6ST (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 is phosphorylated (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Sustained activation of SRC kinase by SHP2 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
FRS-mediated FGFR2 signaling (Canis familiaris)
Activated FGFR2 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
FRS-mediated FGFR3 signaling (Canis familiaris)
Activated FGFR3 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4 phosphorylates PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Spry regulation of FGF signaling (Canis familiaris)
PPTN11 dephosphorylates SPRY2 (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET activates PTPN11 (Canis familiaris)
GAB1 binds PTPN11 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
SHP2 binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Phosphorylation of SHP2 by SFKs (Canis familiaris)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2 interacts with p-KIT (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PTPN11 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PMT9
Reference Genes
ENSEMBL:ENSCAFG00845021271.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021271.1
Other Identifiers
477488
Cfa.10583.1.A1_at
CfaAffx.14053.1.S1_at
GO:0000077
GO:0000278
GO:0001784
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005634
GO:0005737
GO:0006470
GO:0006629
GO:0006641
GO:0006886
GO:0006913
GO:0007155
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0016791
GO:0019901
GO:0021697
GO:0022414
GO:0023052
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0032331
GO:0032480
GO:0032528
GO:0032728
GO:0032755
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035855
GO:0036211
GO:0036302
GO:0038127
GO:0042445
GO:0042593
GO:0043226
GO:0043254
GO:0043408
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048609
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050731
GO:0050839
GO:0050886
GO:0051428
GO:0051463
GO:0055085
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0065003
GO:0070374
GO:0071364
GO:0140096
GO:1990782
Participates
as an input of
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Canis familiaris)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
Activated FGFR2:p-FRS bind to PPTN11 (Canis familiaris)
SHP2 phosphatase binds CTLA-4 (Canis familiaris)
PTPN11 binds p-Y759-IL6ST (Canis familiaris)
SHP2 binds to the active receptor (Canis familiaris)
GAB1 binds PTPN11 (Canis familiaris)
Activated FGFR1:p-FRS bind to PPTN11 (Canis familiaris)
SHP2 interacts with p-KIT (Canis familiaris)
Interaction of PECAM-1 and SHP-2 (Canis familiaris)
Interaction of Tie2 and Shp2 (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
Activated FGFR4:p-FRS bind to PPTN11 (Canis familiaris)
Activated FGFR3:p-FRS bind to PPTN11 (Canis familiaris)
as a component of
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Canis familiaris)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PECAM-1:SHP-2 complex [plasma membrane] (Canis familiaris)
pTie2 and SHP2 complex [plasma membrane] (Canis familiaris)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Canis familiaris)
as a member of
PTPN6,PTPN11 [cytosol] (Canis familiaris)
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(Canis familiaris)
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-p-Y542,Y580-PTPN11 [cytosol]
Inferred From
PTPN11 [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSCAFG00845021271
,
ENSCAFT00845037668
,
ENSCAFP00845029515
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