Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PAK1 [cytosol]
Stable Identifier
R-CFA-162629
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PAK1, A0A8I3NMF7
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
PAK1 binds RAC1:GTP (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Ephrin signaling (Canis familiaris)
PAK binds RAC and bPIX (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
PAK1/3, 2 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1/3, 2 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAKs autophosphorylate (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
PAK1/3, 2 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1/3, 2 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
L1CAM interactions (Canis familiaris)
Signal transduction by L1 (Canis familiaris)
Interaction of PAK1 with Rac1-GTP (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Semaphorin interactions (Canis familiaris)
Sema3A PAK dependent Axon repulsion (Canis familiaris)
Activation of PAK by Rac1 (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Regulation of T cell activation by CD28 family (Canis familiaris)
Co-stimulation by CD28 (Canis familiaris)
CD28 dependent Vav1 pathway (Canis familiaris)
Activation of PAKs by RAC1 and CDC42 (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Generation of second messenger molecules (Canis familiaris)
NCK binds PAK (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
p-SLP-76:NCK:PAK [cytosol] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CD209 (DC-SIGN) signaling (Canis familiaris)
PAK phosphorylates p21 RAF1 on S338 (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
PAK dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
PAK dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
PAK dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
PAK dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Autophosphorylation of PAK1 (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1 and CDC42 activate PAK1 (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
Activation of PAKs by RAC1 and CDC42 (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Autophosphorylation of PAK1,2,3 (Canis familiaris)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through CDC42 (Canis familiaris)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 binds ARHGEF6 (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1:ARHGEF6 complex binds G-protein beta-gamma complex (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Canis familiaris)
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFR2 mediated vascular permeability (Canis familiaris)
PAK1-3 autophosphorylates (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1-3 dimer disassociates (Canis familiaris)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1 binds PAK1-3 (Canis familiaris)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1,2,3 dimer [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases activate PAKs (Canis familiaris)
Autophosphorylation of PAK1,2,3 (Canis familiaris)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
NF2 binds PAK1 (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1:NF2 [plasma membrane] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1 and CDC42 activate PAK1 (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 binds effectors at the plasma membrane (Canis familiaris)
CDC42 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
CDC42:GTP:CDC42 effectors [plasma membrane] (Canis familiaris)
CDC42 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 binds effectors at the plasma membrane (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC3 GTPase cycle (Canis familiaris)
RAC3 binds effectors at the plasma membrane (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RAC3:GTP:RAC3 effectors [plasma membrane] (Canis familiaris)
RAC3 effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOH GTPase cycle (Canis familiaris)
RHOH binds effectors at the plasma membrane (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOH:GTP:RHOH effectors [plasma membrane] (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOQ GTPase cycle (Canis familiaris)
RHOQ binds effectors at the plasma membrane (Canis familiaris)
RHOQ effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Canis familiaris)
RHOQ effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOU GTPase cycle (Canis familiaris)
RHOU binds effectors at the plasma membrane (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOV GTPase cycle (Canis familiaris)
RHOV binds effectors at the plasma membrane (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
RHOV:GTP:RHOV effectors [plasma membrane] (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
PAK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NMF7
Gene Names
PAK1
Reference Genes
ENSEMBL:ENSCAFG00845009162.1
UCSC:A0A8I3NMF7 PAK1
Other Identifiers
607885
Cfa.3213.1.A1_at
CfaAffx.8367.1.S1_s_at
GO:0001726
GO:0003824
GO:0004672
GO:0004674
GO:0005518
GO:0005524
GO:0005654
GO:0005737
GO:0005829
GO:0005884
GO:0005886
GO:0005911
GO:0006325
GO:0006338
GO:0006974
GO:0007010
GO:0008092
GO:0008284
GO:0016477
GO:0016740
GO:0030036
GO:0030335
GO:0031116
GO:0031267
GO:0032956
GO:0032991
GO:0033138
GO:0033148
GO:0035556
GO:0042060
GO:0043015
GO:0043408
GO:0048012
GO:0048754
GO:0048870
GO:0050770
GO:0051496
GO:0060244
GO:0090063
GO:0140096
GO:1903608
Participates
as a member of
PAK1/3, 2 [cytosol] (Canis familiaris)
PAK1,2,3 [cytosol] (Canis familiaris)
as an output of
Interaction of PAK1 with Rac1-GTP (Canis familiaris)
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex (Canis familiaris)
RAC1 and CDC42 activate PAK1 (Canis familiaris)
as an input of
PAK1 binds ARHGEF6 (Canis familiaris)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Canis familiaris)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Canis familiaris)
PAK1 dimer [cytosol] (Canis familiaris)
Other forms of this molecule
PAK1 [plasma membrane]
phospho-PAK1 [plasma membrane]
phospho-PAK1 [cytosol]
Inferred From
Active PAK1 [cytosol]
(Homo sapiens)
PAK1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845012560
,
ENSCAFT00845016147
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text