Reactome | Active mTORC1 complex [lysosomal membrane]

Active mTORC1 complex [lysosomal membrane]

Stable Identifier

R-CFA-165678

Type

Complex

Species

Canis familiaris

Compartment

lysosomal membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Canis familiaris)
RHEB:GTP [lysosomal membrane] (Canis familiaris)

Participates

as an input of

AKT1S1 (PRAS40) binds mTORC1 (Canis familiaris)
AMPK phosphorylates Raptor in the mTORC1 complex (Canis familiaris)
Rheb in the MTORC1 complex hydrolyses GTP (Canis familiaris)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Canis familiaris)
Active MTORC1 binds the ULK1 complex (Canis familiaris)

as a component of

mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Canis familiaris)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Canis familiaris)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Canis familiaris)

as an output of

Formation of active mTORC1 complex (Canis familiaris)

This entity regulates

Negatively

MAF1 translocates to the nucleus (Canis familiaris)

Inferred From

Active mTORC1 complex [lysosomal membrane] (Homo sapiens)

MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)

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