Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-IRF3 [cytosol]
Stable Identifier
R-CFA-166258
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-4S,T404-IRF3, A0A8I3PLU0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
STING mediated induction of host immune responses (Canis familiaris)
IRF3-mediated induction of type I IFN (Canis familiaris)
Dimerized phospho-IRF3 migrates to the nucleus (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
p-T,4S-IRF3 is dimerized (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
IRF3 mediated activation of type 1 IFN (Canis familiaris)
Dimerized phospho-IRF3 migrates to the nucleus (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
p-T,4S-IRF3 is dimerized (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TICAM1-dependent activation of IRF3/IRF7 (Canis familiaris)
Dimerization of phosphorylated IRF3/IRF7 (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Canis familiaris)
Dimerization of phosphorylated IRF3/IRF7 (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Canis familiaris)
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
phospho-IRF3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PLU0
Gene Names
IRF3
Reference Genes
ENSEMBL:ENSCAFG00845023315.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845023315.1 IRF3
Other Identifiers
476412
Cfa.18322.1.S1_at
Cfa.2729.1.S1_s_at
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001216
GO:0001227
GO:0001228
GO:0002376
GO:0002753
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0009617
GO:0010468
GO:0012501
GO:0019904
GO:0023052
GO:0031663
GO:0032481
GO:0032496
GO:0032727
GO:0032728
GO:0035666
GO:0042802
GO:0042803
GO:0042981
GO:0043226
GO:0043330
GO:0043565
GO:0045893
GO:0045944
GO:0050727
GO:0051607
GO:0060337
GO:0060340
GO:0071222
GO:0097300
GO:0098542
GO:0098586
GO:0140110
GO:1990837
GO:1990841
Participates
as an input of
p-T,4S-IRF3 is dimerized (Canis familiaris)
Dimerization of phosphorylated IRF3/IRF7 (Canis familiaris)
as an output of
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex (Canis familiaris)
as a component of
p-T,4S-IRF3:p-T,4S-IRF3 [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-IRF3 [nucleoplasm]
phospho-IRF3 [nucleoplasm]
IRF3 [cytosol]
Inferred From
p-4S,T404-IRF3,p-S477,S479-IRF7 [cytosol]
(Homo sapiens)
p-4S,T404-IRF3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 396 (in Homo sapiens)
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 398 (in Homo sapiens)
Coordinate
398
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 402 (in Homo sapiens)
Coordinate
402
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 405 (in Homo sapiens)
Coordinate
405
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 404 (in Homo sapiens)
Coordinate
404
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
OpenTargets
ENSG00000126456
Ensembl
ENSCAFP00845032284
,
ENSCAFG00845023315
,
ENSCAFT00845041192
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text