Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TRAF6 [cytosol]
Stable Identifier
R-CFA-166366
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
TRAF6, E2RDE8
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Auto-ubiquitination of TRAF6 (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Translocation of TRAF6 to CBM complex (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 is K63 poly-ubiquitinated (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb (Canis familiaris)
hp-IRAK1:3xTRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb [cytosol] (Canis familiaris)
hp-IRAK1:3xTRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p62:MEKK3 binds to TRAF6 (Canis familiaris)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Alpha-protein kinase 1 signaling pathway (Canis familiaris)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
K63polyUb-TRAF6 ubiquitinates TAK1 (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MALT1 oligomers (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 oligomer autoubiquitinates (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Canis familiaris)
TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 oligomerizes (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane] (Canis familiaris)
TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Auto-ubiquitination of TRAF6 (Canis familiaris)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Canis familiaris)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Canis familiaris)
TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Oligomerization of TRAF6 (Canis familiaris)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Canis familiaris)
CBM oligomer:TRAF6 [plasma membrane] (Canis familiaris)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Canis familiaris)
MALT1oligomer:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 oligomer [plasma membrane] (Canis familiaris)
CBM oligomer:TRAF6 oligomer [plasma membrane] (Canis familiaris)
TRAF6 oligomer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)
DAG:p-5Y-PKC-theta:CBM oligomer:TRAF6 [plasma membrane] (Canis familiaris)
CBM oligomer:TRAF6 [plasma membrane] (Canis familiaris)
BCL10 oligomer:MALT1 oligomer:TRAF6 [cytosol] (Canis familiaris)
MALT1oligomer:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Pellino ubiquitinates hp-IRAK1 (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK2 mediated activation of TAK1 complex (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Canis familiaris)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA (Canis familiaris)
OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Canis familiaris)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
OTUD7B,TNFAIP3 deubiquitinate TRAF6 (Canis familiaris)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 (Canis familiaris)
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
USP4 deubiquitinate TRAF2,TRAF6 (Canis familiaris)
TRAF2, TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signalling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRIF signals cell death from the nucleus (Canis familiaris)
TRAF6 binds to p75NTR:NRIF (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 polyubiquitinates NRIF (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Regulated proteolysis of p75NTR (Canis familiaris)
p75NTR ICD signals to NF-kB (Canis familiaris)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
IRAK interacts with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
MYD88 dissociates (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
p62 recruits an atypical PKC (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:E2RDE8
Gene Names
TRAF6
Reference Genes
ENSEMBL:ENSCAFG00000006813
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000006813 TRAF6
Other Identifiers
100688110
CfaAffx.11138.1.S1_s_at
GO:0000122
GO:0000209
GO:0001503
GO:0001701
GO:0001843
GO:0002376
GO:0002637
GO:0002726
GO:0003674
GO:0004842
GO:0005164
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006464
GO:0006950
GO:0006955
GO:0006974
GO:0007155
GO:0007165
GO:0007249
GO:0007250
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0009058
GO:0009790
GO:0009887
GO:0009898
GO:0016567
GO:0016740
GO:0019886
GO:0019899
GO:0019901
GO:0030154
GO:0030316
GO:0031435
GO:0031624
GO:0031625
GO:0031666
GO:0031996
GO:0032147
GO:0032735
GO:0032743
GO:0032755
GO:0032991
GO:0033209
GO:0034641
GO:0035631
GO:0042088
GO:0042102
GO:0042475
GO:0042592
GO:0042802
GO:0042826
GO:0042981
GO:0043011
GO:0043122
GO:0043123
GO:0043167
GO:0043226
GO:0043422
GO:0043507
GO:0045453
GO:0045672
GO:0045892
GO:0045944
GO:0046330
GO:0046849
GO:0046872
GO:0047485
GO:0048468
GO:0048471
GO:0048646
GO:0048856
GO:0050852
GO:0051091
GO:0051092
GO:0051865
GO:0061630
GO:0070498
GO:0070534
GO:0070555
GO:0071222
GO:0071345
GO:0097400
GO:1901224
GO:1904996
GO:2000679
Participates
as a member of
RNF128,TRAF3,TRAF6,RHOA,TP53 [cytosol] (Canis familiaris)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
TRAF2, TRAF6 [cytosol] (Canis familiaris)
as a component of
OTUD7B,TNFAIP3,ZRANB1:TRAF6 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
NF-kB:p75NTR ICD:TRAF6 [cytosol] (Canis familiaris)
TRAF6 homotrimer [cytosol] (Canis familiaris)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
hp-IRAK1:3xTRAF6 [cytosol] (Canis familiaris)
p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] (Canis familiaris)
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane] (Canis familiaris)
TRAF6 trimer bound to CBM complex [plasma membrane] (Canis familiaris)
MALT1oligomer:TRAF6 [cytosol] (Canis familiaris)
MEKK1:activated TRAF6 [cytosol] (Canis familiaris)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Canis familiaris)
TRAF6 E3/E2 ubiquitin ligase complex [cytosol] (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Canis familiaris)
ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
as an input of
IRAK interacts with TRAF6 (Canis familiaris)
p75NTR ICD signals to NF-kB (Canis familiaris)
p62:MEKK3 binds to TRAF6 (Canis familiaris)
Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
IRAK1 induces oligomerisation of TRAF6 (Canis familiaris)
TRAF6 oligomerizes (Canis familiaris)
TRAF6 binds MALT1 oligomers (Canis familiaris)
Translocation of TRAF6 to CBM complex (Canis familiaris)
Oligomerization of TRAF6 (Canis familiaris)
Recruitment of TRAF6 to CBM complex by binding to MALT1 (Canis familiaris)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Canis familiaris)
TRAF6 binds MEKK1 (Canis familiaris)
TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)
ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)
IRAK2 induces TRAF6 oligomerization (Canis familiaris)
as a repeated unit of
TRAF6 oligomer [cytosol] (Canis familiaris)
Other forms of this molecule
TRAF6 [cytosol]
TRAF6 [cytosol]
TRAF6 [endosome membrane]
TRAF6 [endosome membrane]
TRAF6 [plasma membrane]
TRAF6 [plasma membrane]
TRAF6 [cytosol]
Inferred From
TRAF6 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000175104
Ensembl
ENSCAFG00000006813
,
ENSCAFP00000010159
,
ENSCAFT00000010962
VGNC
52058
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text