Reactome | ABI1 [cytosol]

ABI1 [cytosol]

Stable Identifier

R-CFA-1671643

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ABI1, A0A8I3ML42

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
      - ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)
      - p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        ABI [cytosol] (Canis familiaris)
        
        ABI1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3ML42

Gene Names

ABI1

Reference Genes

BioGPS Gene:607247 ABI1

ENSEMBL:ENSCAFG00845003709.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845003709.1 ABI1

Monarch:607247 ABI1

NCBI Gene:607247 ABI1

Reference Transcript

RefSeq:XM_003433709.3 ABI1

Other Identifiers

607247

Cfa.20999.1.S1_s_at

Cfa.258.1.S1_at

CfaAffx.7474.1.S1_s_at

GO:0001756

GO:0005515

GO:0017124

GO:0030027

GO:0030154

GO:0030296

GO:0031209

GO:0031252

GO:0032433

GO:0035591

GO:0035855

GO:0043005

GO:0048813

GO:0048856

GO:0060090

GO:0072673

GO:0098772

Participates

as a candidate of

as a member of

ABI [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-ABI1 [cytosol]

Inferred From

ABI1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003433757.1

OpenTargets

ENSG00000136754

Ensembl

ENSCAFG00845003709, ENSCAFT00845006698, ENSCAFP00845005330

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