Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
IKBKG [cytosol]
Stable Identifier
R-CFA-168108
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
IKBKG, A0A8I3S792
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Canis familiaris)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA) (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
PKR-mediated signaling (Canis familiaris)
IKK complex is activated by PKR (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NEMO binds polyubiquitinated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
CYLD deubiquitinates NEMO (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
RIP2 binds NEMO (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
RIP2 induces K63-linked ubiquitination of NEMO (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1 is activated (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
IKK complex recruitment mediated by RIP1 (Canis familiaris)
IKBKG subunit of IKK complex binds polyubiquinated RIP1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
IRAK1 recruits IKK complex (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation (Canis familiaris)
NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP kinase activation (Canis familiaris)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
activated TAK1 mediates p38 MAPK activation (Canis familiaris)
activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
Activated TAK complexes [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
GNB2L1 binds IKKA:IKKB:NEMO (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
IKKA:IKKB:NEMO:GNB2L1 [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S792
Gene Names
IKBKG
Reference Genes
ENSEMBL:ENSCAFG00845029634.1
UCSC:A0A8I3S792 IKBKG
Reference Transcript
RefSeq:XM_003640238.3 IKBKG
Other Identifiers
CfaAffx.29977.1.S1_at
GO:0000151
GO:0000922
GO:0005634
GO:0005737
GO:0005829
GO:0006355
GO:0006974
GO:0007249
GO:0008385
GO:0019904
GO:0031593
GO:0031625
GO:0032991
GO:0035591
GO:0042742
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0045944
GO:0046872
GO:0046982
GO:0050862
GO:0051650
GO:0060090
GO:0065003
GO:0070530
GO:0072686
GO:0098542
GO:1990450
GO:1990459
Participates
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
as a component of
p-Y187,Y198-CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
EIF2AK2:CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
IKBKG:N4BP1 [cytosol] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
PAMP:NOD oligomer:RIP2:NEMO [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
CHUK:IKBKB:IKBKG [cytosol] (Canis familiaris)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Canis familiaris)
as an input of
N4BP1 binds IKBKG (Canis familiaris)
RIP2 binds NEMO (Canis familiaris)
CHUK, IKBKB and IKBKG form IKK complex (Canis familiaris)
Other forms of this molecule
IKBKG [nucleoplasm]
IKBKG [cytosol]
IKBKG [cytosol]
Inferred From
IKBKG [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_003640286.2
ENSEMBL
ENSCAFP00845041208
,
ENSCAFT00845052518
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
