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RIPK1 [cytosol]
Stable Identifier
R-CFA-168651
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
RIPK1, A0A8I3S2L7
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
IKK complex recruitment mediated by RIP1 (Canis familiaris)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRIF-mediated programmed cell death (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIP3 binds TRIF to mediate necroptosis (Canis familiaris)
RIP3:TICAM1:activated TLR4 [endosome membrane] (Canis familiaris)
RIP3:RIP1:TICAM1:activated TLR4 [endosome membrane] (Canis familiaris)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRIF:activated TLR4 [endosome membrane] (Canis familiaris)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 (Canis familiaris)
TNFAIP3:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 (Canis familiaris)
TNFAIP3:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Canis familiaris)
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
USP21 deubiquitinates RIPK1,DDX58 (Canis familiaris)
USP21:RIPK1,DDX58 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Dimerization of procaspase-8 (Canis familiaris)
TNF-mediated dimerization of procaspase-8 (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Regulation by c-FLIP (Canis familiaris)
Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
RIPK1 is phosphorylated (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK3 is phosphorylated (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
CASP8 activity is inhibited (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 is cleaved by CASP8 (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Small molecule inhibitor binds RIPK1, RIPK3 (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3:sorafenib, ponatinib, pazopanib [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Canis familiaris)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 binds STUB1 (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 is cleaved by CASP8 (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1 is cleaved by CASP8:FLIP(L) (Canis familiaris)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
ULK1 phosphorylates RIPK1 at S357 (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S2L7
Gene Names
RIPK1
Reference Genes
ENSEMBL:ENSCAFG00845017400.1
UCSC:A0A8I3S2L7 RIPK1
Reference Transcript
RefSeq:XM_005639981.2 RIPK1
Other Identifiers
CfaAffx.14700.1.S1_at
GO:0003824
GO:0004672
GO:0004674
GO:0005123
GO:0005524
GO:0005739
GO:0006355
GO:0006915
GO:0006950
GO:0006979
GO:0007165
GO:0007166
GO:0010628
GO:0012501
GO:0016740
GO:0030163
GO:0031264
GO:0031349
GO:0031625
GO:0032757
GO:0032760
GO:0032991
GO:0034612
GO:0035556
GO:0042802
GO:0042803
GO:0043065
GO:0043068
GO:0043123
GO:0043124
GO:0043226
GO:0043235
GO:0044877
GO:0045651
GO:0045944
GO:0046330
GO:0050729
GO:0060545
GO:0062100
GO:0065003
GO:0070105
GO:0070266
GO:0070513
GO:0071345
GO:0071356
GO:0097191
GO:0097342
GO:0097343
GO:0097527
GO:0140096
GO:1903800
GO:1990000
GO:2001237
GO:2001238
Participates
as a component of
TNFAIP3:RIPK1 [cytosol] (Canis familiaris)
USP21:RIPK1,DDX58 [cytosol] (Canis familiaris)
TNFalpha:TNFR1:TRADD:TRAF2:TRAF1:RIPK1 [plasma membrane] (Canis familiaris)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
RIPK1:RIPK3 [cytosol] (Canis familiaris)
RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Canis familiaris)
as a member of
TRAF2,TRAF6,IKBKG,RIPK1 [cytosol] (Canis familiaris)
as an input of
RIPK1 binds STUB1 (Canis familiaris)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)
TRIF:activated TLR3/TLR4 complex recruits RIP1 (Canis familiaris)
Other forms of this molecule
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
phospho-RIPK1 [cytosol]
RIPK1 [cytosol]
Inferred From
RIPK1, DDX58 [cytosol]
(Homo sapiens)
RIPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005640038.1
ENSEMBL
ENSCAFP00845024153
,
ENSCAFT00845030809
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