Reactome | SYT1 [plasma membrane]

SYT1 [plasma membrane]

Stable Identifier

R-CFA-168786

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

SYT1, A0A8I3N2E5

Locations in the PathwayBrowser

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Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - STON2 binds SYT proteins (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT dimers [plasma membrane] (Canis familiaris)
        
        SYT1 dimer [plasma membrane] (Canis familiaris)
        
        SYT1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N2E5

Gene Names

SYT1

Reference Genes

ENSEMBL:ENSCAFG00845007651.1

UCSC:A0A8I3N2E5 SYT1

Other Identifiers

482579

Cfa.1368.1.A1_at

CfaAffx.9607.1.S1_at

CfaAffx.9611.1.S1_at

GO:0001786

GO:0005509

GO:0005544

GO:0005737

GO:0005794

GO:0005886

GO:0007269

GO:0008021

GO:0008289

GO:0014059

GO:0016020

GO:0016050

GO:0016079

GO:0016192

GO:0017075

GO:0017158

GO:0019905

GO:0030141

GO:0030276

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0042584

GO:0042734

GO:0043005

GO:0043226

GO:0045202

GO:0046872

GO:0048306

GO:0048488

GO:0048791

GO:0050750

GO:0050806

GO:0051966

GO:0061669

GO:0061891

GO:0070382

GO:0071277

GO:0071911

GO:0098746

GO:0098978

GO:0099502

GO:0140299

GO:1903235

GO:1903861

Participates

as a component of

SYT1 dimer [plasma membrane] (Canis familiaris)

as an output of

Other forms of this molecule

SYT1 [clathrin-coated endocytic vesicle membrane]

SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]

SYT1 [clathrin-sculpted glutamate transport vesicle membrane]

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

SYT1 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred From

SYT1 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFT00845013503, ENSCAFP00845010478

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