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FRS2 [plasma membrane]
Stable Identifier
R-CFA-170963
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
FRS2, A0A8I3P4L9
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
FRS-mediated FGFR1 signaling (Canis familiaris)
Activated FGFR1 binds FRS2 (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1 phosphorylates FRS2 (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Negative regulation of FGFR1 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
FRS-mediated FGFR2 signaling (Canis familiaris)
Activated FGFR2 binds FRS2 (Canis familiaris)
Activated FGFR2:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR2 phosphorylates FRS2 (Canis familiaris)
Activated FGFR2:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Negative regulation of FGFR2 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 (Canis familiaris)
Activated FGFR2:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
FRS-mediated FGFR3 signaling (Canis familiaris)
Activated FGFR3 binds FRS2 (Canis familiaris)
Activated FGFR3:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR3 phosphorylates FRS2 (Canis familiaris)
Activated FGFR3:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Negative regulation of FGFR3 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2 (Canis familiaris)
Activated FGFR3:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
FRS-mediated FGFR4 signaling (Canis familiaris)
Activated FGFR4 binds FRS2 (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4 phosphorylates FRS2 (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Negative regulation of FGFR4 signaling (Canis familiaris)
Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2 (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RND1 GTPase cycle (Canis familiaris)
RND1 binds effectors (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
RND1:GTP:RND1 effectors [plasma membrane] (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
RND2 GTPase cycle (Canis familiaris)
RND2 binds effectors (Canis familiaris)
RND2 effectors [cytosol] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
RND2:GTP:RND2 effectors [plasma membrane] (Canis familiaris)
RND2 effectors [cytosol] (Canis familiaris)
FRS2 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3P4L9
Gene Names
FRS2
Reference Genes
BioGPS Gene:474444 FRS2
ENSEMBL:ENSCAFG00845017484.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845017484.1 FRS2
KEGG Gene (Canis lupus familiaris):474444 FRS2
Monarch:474444 FRS2
NCBI Gene:474444 FRS2
Reference Transcript
RefSeq:XM_005625613.2 FRS2
RefSeq:XM_005625611.1 FRS2
RefSeq:XM_005625610.2 FRS2
RefSeq:XM_005625612.2 FRS2
Other Identifiers
474444
Cfa.19573.1.S1_at
Cfa.1958.1.S1_at
Cfa.1958.2.A1_at
CfaAffx.1604.1.S1_s_at
GO:0001702
GO:0001759
GO:0002088
GO:0003281
GO:0005068
GO:0005104
GO:0005168
GO:0005737
GO:0005886
GO:0005911
GO:0005912
GO:0007169
GO:0007405
GO:0008543
GO:0008595
GO:0012501
GO:0022414
GO:0023052
GO:0030154
GO:0030900
GO:0042981
GO:0043410
GO:0046619
GO:0048856
GO:0050678
GO:0060090
GO:0060527
GO:0070307
GO:0070372
GO:2000726
Participates
as a member of
RND2 effectors [cytosol] (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)
Activated FGFR4 binds FRS2 (Canis familiaris)
Activated FGFR1 binds FRS2 (Canis familiaris)
Activated FGFR3 binds FRS2 (Canis familiaris)
Activated FGFR2 binds FRS2 (Canis familiaris)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR4:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR1:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR3:FRS2 [plasma membrane] (Canis familiaris)
Activated FGFR2:FRS2 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-FRS2 [cytosol]
FRS2 [cytosol]
phospho-FRS2 [cytosol]
phospho-FRS2 [plasma membrane]
phospho-FRS2 [plasma membrane]
Inferred From
FRS2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_005625668.1
,
XP_005625669.1
,
XP_005625667.1
,
XP_005625670.1
OpenTargets
ENSG00000166225
Ensembl
ENSCAFG00845017484
,
ENSCAFT00845030983
,
ENSCAFP00845024277
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