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SMAD2,3 [cytosol]
Stable Identifier
R-CFA-171172
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
cytosol
Synonyms
R-SMAD2,3
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
SMAD2/3:PMEPA1 [plasma membrane] (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
SMAD2,3 [cytosol] (Canis familiaris)
Participants
members
SMAD2 [cytosol]
(Canis familiaris)
Madh3 [cytosol]
(Canis familiaris)
Participates
as an input of
PMEPA1 sequesters unphosphorylated SMAD2/3 (Canis familiaris)
MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3 (Canis familiaris)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
as a component of
SMAD2/3:PMEPA1 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
as an output of
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
Inferred From
SMAD2,3 [cytosol]
(Homo sapiens)
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