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SMAD7 [cytosol]
Stable Identifier
R-CFA-173478
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SMAD7, F6XXN3
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Canis familiaris)
SMAD7:SMURF2 [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Canis familiaris)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,,Ub-KEAP1,SMAD7:SMURF2:Ub-TGFBR1 [cytosol] (Canis familiaris)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by BMP (Canis familiaris)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Canis familiaris)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-SMAD:SMURF [cytosol] (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-Smad competes with R-Smad1/5/8 for type I receptor (Canis familiaris)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-SMAD [cytosol] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
Degradation of TGF-beta receptor complex (Canis familiaris)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Canis familiaris)
SMAD7 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F6XXN3
Gene Names
SMAD7
Reference Genes
BioGPS Gene:490570 SMAD7
ENSEMBL:ENSCAFG00000019069
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000019069 SMAD7
Monarch:490570 SMAD7
NCBI Gene:490570 SMAD7
Reference Transcript
RefSeq:XM_845400.3 SMAD7
Other Identifiers
490570
CfaAffx.29112.1.S1_at
GO:0000122
GO:0001650
GO:0001657
GO:0002376
GO:0002725
GO:0003013
GO:0003674
GO:0003677
GO:0005515
GO:0005518
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0006355
GO:0006464
GO:0006950
GO:0007155
GO:0007165
GO:0007179
GO:0008013
GO:0008150
GO:0008283
GO:0009056
GO:0009058
GO:0009653
GO:0010717
GO:0010801
GO:0010944
GO:0016342
GO:0019899
GO:0022409
GO:0022607
GO:0030154
GO:0030279
GO:0030509
GO:0030512
GO:0030514
GO:0031397
GO:0031398
GO:0031625
GO:0032436
GO:0032925
GO:0032991
GO:0033137
GO:0034330
GO:0034333
GO:0034616
GO:0034629
GO:0034641
GO:0034713
GO:0040007
GO:0043167
GO:0043226
GO:0043433
GO:0046872
GO:0048185
GO:0048844
GO:0048856
GO:0050821
GO:0051444
GO:0055010
GO:0055117
GO:0060389
GO:0060394
GO:0060395
GO:0060412
GO:0070411
GO:0071144
GO:0071560
GO:0140416
GO:1902731
GO:1903043
GO:1990830
GO:2000317
GO:2000320
Participates
as a component of
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Canis familiaris)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Canis familiaris)
SMAD7:SMURF2 [cytosol] (Canis familiaris)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Canis familiaris)
as a member of
I-SMAD [cytosol] (Canis familiaris)
as an input of
BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)
Other forms of this molecule
SMAD7 [nucleoplasm]
Inferred From
SMAD7 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_850493.2
OpenTargets
ENSG00000101665
Ensembl
ENSCAFG00000019069
,
ENSCAFP00000028133
,
ENSCAFT00000030280
VGNC
46524
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