Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
Stable Identifier
R-CFA-173511
Type
Set [DefinedSet]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD:CO-SMAD complex
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Signaling by NODAL (Canis familiaris)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
FOXO-mediated transcription (Canis familiaris)
FOXO-mediated transcription of cell cycle genes (Canis familiaris)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TRIM33 monoubiquitinates SMAD4 (Canis familiaris)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PPM1A dephosphorylates nuclear SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
TRIM33 monoubiquitinates SMAD4 (Canis familiaris)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
Participants
members
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
(Canis familiaris)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]
(Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm]
(Canis familiaris)
Participates
as an input of
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Canis familiaris)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Canis familiaris)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Canis familiaris)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Canis familiaris)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Canis familiaris)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Canis familiaris)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Canis familiaris)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Canis familiaris)
as a component of
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Canis familiaris)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Canis familiaris)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Canis familiaris)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Canis familiaris)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Canis familiaris)
as an output of
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
Inferred From
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
(Homo sapiens)
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
