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APOE [extracellular region]
Stable Identifier
R-CFA-174646
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
P18649
Locations in the PathwayBrowser
Expand all
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of fat-soluble vitamins (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
CR:atREs binds apoE and HSPG (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
LPL hydrolyses TGs from mature CMs (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Nascent CMs transform into mature CMs (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Sensory Perception (Canis familiaris)
Visual phototransduction (Canis familiaris)
Retinoid metabolism and transport (Canis familiaris)
CR:atREs binds apoE and HSPG (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
LPL hydrolyses TGs from mature CMs (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Canis familiaris)
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
CR:atREs [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Nascent CMs transform into mature CMs (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Transport of small molecules (Canis familiaris)
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
Chylomicron assembly (Canis familiaris)
nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Plasma lipoprotein clearance (Canis familiaris)
Chylomicron clearance (Canis familiaris)
chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex (Canis familiaris)
chylomicron remnant:apoE complex [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Plasma lipoprotein remodeling (Canis familiaris)
Chylomicron remodeling (Canis familiaris)
TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant:apoE complex [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
chylomicron remnant [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
HDL remodeling (Canis familiaris)
Spherical HDL binds C and E apolipoproteins (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Binding and Uptake of Ligands by Scavenger Receptors (Canis familiaris)
Scavenging by Class A Receptors (Canis familiaris)
MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed (Canis familiaris)
MSR1:Ligand [plasma membrane] (Canis familiaris)
Ligands of MSR1 [extracellular region] (Canis familiaris)
APOE [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:P18649
Reference Genes
BioGPS Gene:476438
ENSEMBL:ENSCAFG00000004617
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000004617.5
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805002979
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006705.1
KEGG Gene (Canis lupus familiaris):476438
Monarch:476438
NCBI Gene:476438
Reference Transcript
RefSeq:XM_533644.5
RefSeq:XM_005616460.2
RefSeq:XM_860950.3
Other Identifiers
476438
CfaAffx.7867.1.S1_s_at
GO:0001540
GO:0001937
GO:0002021
GO:0002376
GO:0003013
GO:0005102
GO:0005215
GO:0005319
GO:0005543
GO:0005576
GO:0005615
GO:0005768
GO:0005783
GO:0005794
GO:0006351
GO:0006355
GO:0006629
GO:0006641
GO:0006707
GO:0006869
GO:0006874
GO:0006898
GO:0006954
GO:0006979
GO:0007186
GO:0007263
GO:0007616
GO:0008092
GO:0008201
GO:0008203
GO:0008289
GO:0010467
GO:0010468
GO:0010544
GO:0010596
GO:0010629
GO:0010875
GO:0010877
GO:0010976
GO:0010977
GO:0012501
GO:0015909
GO:0016192
GO:0016209
GO:0017038
GO:0019068
GO:0019899
GO:0019934
GO:0023052
GO:0030154
GO:0030163
GO:0030195
GO:0030312
GO:0031012
GO:0031175
GO:0031410
GO:0032438
GO:0032489
GO:0032805
GO:0033344
GO:0033700
GO:0034330
GO:0034360
GO:0034361
GO:0034362
GO:0034363
GO:0034364
GO:0034372
GO:0034374
GO:0034375
GO:0034380
GO:0034382
GO:0034384
GO:0034447
GO:0035641
GO:0042060
GO:0042157
GO:0042158
GO:0042159
GO:0042311
GO:0042470
GO:0042627
GO:0042632
GO:0042802
GO:0042803
GO:0042981
GO:0042982
GO:0043083
GO:0043226
GO:0043254
GO:0043395
GO:0043537
GO:0043691
GO:0044794
GO:0044877
GO:0045088
GO:0045541
GO:0045807
GO:0045893
GO:0046889
GO:0046911
GO:0046983
GO:0048156
GO:0048662
GO:0048844
GO:0048856
GO:0048870
GO:0050709
GO:0050728
GO:0050750
GO:0050807
GO:0050877
GO:0051044
GO:0051246
GO:0051248
GO:0051651
GO:0055065
GO:0055088
GO:0055089
GO:0060228
GO:0060999
GO:0061024
GO:0061136
GO:0061771
GO:0065003
GO:0070062
GO:0070326
GO:0070328
GO:0070374
GO:0071813
GO:0071830
GO:0071831
GO:0072359
GO:0090090
GO:0090181
GO:0090205
GO:0090209
GO:0097006
GO:0097113
GO:0097114
GO:0097487
GO:0098542
GO:0098754
GO:0098772
GO:0098978
GO:0120020
GO:1900221
GO:1900223
GO:1900272
GO:1902430
GO:1902952
GO:1902991
GO:1902995
GO:1903002
GO:1905890
GO:1905906
GO:1905907
GO:1990777
GO:2000822
Participates
as an input of
CR:atREs binds apoE and HSPG (Canis familiaris)
chylomicron remnant + apoE => chylomicron remnant:apoE complex (Canis familiaris)
Spherical HDL binds C and E apolipoproteins (Canis familiaris)
as a component of
CR:atREs:HSPG:apoE [plasma membrane] (Canis familiaris)
mature CM:atREs [extracellular region] (Canis familiaris)
chylomicron remnant:apoE complex [extracellular region] (Canis familiaris)
chylomicron remnant [extracellular region] (Canis familiaris)
TG-depleted chylomicron [extracellular region] (Canis familiaris)
chylomicron [extracellular region] (Canis familiaris)
spherical HDL:apoC-II:apoC-III:apoE [extracellular region] (Canis familiaris)
as a member of
Ligands of MSR1 [extracellular region] (Canis familiaris)
Other forms of this molecule
APOE [early endosome]
APOE [clathrin-coated endocytic vesicle membrane]
APOE [plasma membrane]
APOE [endocytic vesicle lumen]
phospho-p-APOE [endoplasmic reticulum lumen]
APOE [endoplasmic reticulum lumen]
Inferred From
APOE [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_866043.1
,
XP_005616517.2
,
XP_533644.1
Ensembl
ENSCAFG00845006705
,
ENSCAFT00845011898
,
ENSCAFP00845009282
VGNC
38002
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