Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
P4HB [endoplasmic reticulum lumen]
Stable Identifier
R-CFA-174692
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
endoplasmic reticulum lumen
Synonyms
P4HB, A0A8I3NBI7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
Detoxification of Reactive Oxygen Species (Canis familiaris)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Extracellular matrix organization (Canis familiaris)
Collagen formation (Canis familiaris)
Collagen biosynthesis and modifying enzymes (Canis familiaris)
P4HB binds Collagen chains (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB:Collagen propeptides [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)
4-Hyp collagen propeptides:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines (Canis familiaris)
4-Hyp collagen propeptides:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB:Collagen propeptides [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Prolyl 4-hydroxylases [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-12 family signaling (Canis familiaris)
Interleukin-12 signaling (Canis familiaris)
IL12A binds IL12B (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
IL12B dimerizes (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Interleukin-23 signaling (Canis familiaris)
IL12B binds IL23A (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Peptide hormone metabolism (Canis familiaris)
Insulin processing (Canis familiaris)
ERO1B oxidizes P4HB (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Post-translational protein phosphorylation (Canis familiaris)
FAM20C phosphorylates FAM20C substrates (Canis familiaris)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Canis familiaris)
FAM20C substrates [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Canis familiaris)
FAM20C phosphorylates FAM20C substrates (Canis familiaris)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Canis familiaris)
FAM20C substrates [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
Autoproteolytic cleavage of Hh precursors (Canis familiaris)
NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB forms mixed disulphides with Hh precursors (Canis familiaris)
NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Transport of small molecules (Canis familiaris)
Plasma lipoprotein assembly, remodeling, and clearance (Canis familiaris)
Plasma lipoprotein assembly (Canis familiaris)
Chylomicron assembly (Canis familiaris)
ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
VLDL assembly (Canis familiaris)
MTTP lipidates APOB-100, forming a pre-VLDL (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
MTTP:lomitapide [endoplasmic reticulum lumen] (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
Plasma lipoprotein remodeling (Canis familiaris)
LDL remodeling (Canis familiaris)
MTTP binds lomitapide (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
MTTP:lomitapide [endoplasmic reticulum lumen] (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
P4HB [endoplasmic reticulum lumen] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NBI7
Gene Names
P4HB
Reference Genes
ENSEMBL:ENSCAFG00845009297.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845009297.1 P4HB
Other Identifiers
483369
Cfa.17740.1.S1_at
Cfa.18785.1.S1_s_at
CfaAffx.9756.1.S1_s_at
GO:0003756
GO:0003779
GO:0003824
GO:0004656
GO:0005178
GO:0005783
GO:0005788
GO:0005793
GO:0005829
GO:0005856
GO:0005886
GO:0006457
GO:0006888
GO:0007155
GO:0008092
GO:0009897
GO:0012501
GO:0015035
GO:0016192
GO:0016222
GO:0016491
GO:0016853
GO:0016972
GO:0023052
GO:0030027
GO:0030070
GO:0032991
GO:0034663
GO:0034975
GO:0034976
GO:0043226
GO:0045785
GO:0046598
GO:0046982
GO:0051604
GO:0071456
GO:0098761
GO:0140096
GO:1900026
GO:1902175
Participates
as an input of
ERO1B oxidizes P4HB (Canis familiaris)
P4HB binds Collagen chains (Canis familiaris)
P4HB forms mixed disulphides with Hh precursors (Canis familiaris)
GPX7,8 catalyze peroxidation of P4HB (PDI) (Canis familiaris)
as an output of
P4HB mediates disulfide bond formation in Proinsulin (Canis familiaris)
P4HB:4-Hyp collagen propeptides dissociates (Canis familiaris)
Autoproteolytic cleavage of Hh precursors (Canis familiaris)
as a component of
4-Hyp collagen propeptides:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
P4HB:Collagen propeptides [endoplasmic reticulum lumen] (Canis familiaris)
Prolyl 4-hydroxylases [endoplasmic reticulum lumen] (Canis familiaris)
NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] (Canis familiaris)
MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Canis familiaris)
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Canis familiaris)
Other forms of this molecule
P4HB [endoplasmic reticulum lumen]
phospho-P4HB [endoplasmic reticulum lumen]
Inferred From
P4HB [endoplasmic reticulum lumen]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000185624
Ensembl
ENSCAFP00845012755
,
ENSCAFG00845009297
,
ENSCAFT00845016396
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text