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PIK3CA:PIK3R1 [cytosol]
Stable Identifier
R-CFA-1806218
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PIK3C(1) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K bound to EPOR [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PIK3CA [cytosol]
(Canis familiaris)
PIK3R1 [cytosol]
(Canis familiaris)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3C(1) [cytosol] (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
as an input of
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
as a component of
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
Inferred From
PIK3CA:PIK3R1 [cytosol]
(Homo sapiens)
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