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What is Reactome ?
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Our Logo
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Table of Contents
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AP2S1 [cytosol]
Stable Identifier
R-CFA-182197
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
AP2S1, A0A5F4CSI6
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPH-ephrin mediated repulsion of cells (Canis familiaris)
Clathrin internalises EPH:EFN complexes (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Canis familiaris)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Canis familiaris)
clathrin:AP-2 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
WNT5A-dependent internalization of FZD4 (Canis familiaris)
WNT5A:FZD4 is endocytosed (Canis familiaris)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Canis familiaris)
clathrin:AP-2 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Canis familiaris)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Canis familiaris)
clathrin:AP-2 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
clathrin:AP-2 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
AP-2 directly binds some endocytic cargo (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
AP2:chlorpromazine [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
AP2 binds chlorpromazine (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
AP2:chlorpromazine [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Clathrin recruits PIK3C2A (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Dissociation of clathrin-associated proteins (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
FCHo proteins bind nascent clathrin-coated pit (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
Clathrin-coated vesicle [cytosol] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
Recruitment of AP-2 complex and clathrin (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
CLASP proteins:cargo [plasma membrane] (Canis familiaris)
AP-2:cargo [plasma membrane] (Canis familiaris)
AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
AP2S1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A5F4CSI6
Gene Names
AP2S1
Reference Genes
ENSEMBL:ENSCAFG00000004193
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000004193 AP2S1
Other Identifiers
476427
CfaAffx.7214.1.S1_at
GO:0003674
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005905
GO:0006810
GO:0006886
GO:0008150
GO:0015031
GO:0016192
GO:0030117
GO:0030122
GO:0030674
GO:0031410
GO:0032991
GO:0035615
GO:0043226
GO:0072583
Participates
as a component of
AP-2 Complex [cytosol] (Canis familiaris)
p-T156 AP-2 Complex [cytosol] (Canis familiaris)
Other forms of this molecule
AP2S1 [endolysosome membrane]
AP2S1 [endocytic vesicle membrane]
AP2S1 [plasma membrane]
AP2S1 [clathrin-coated endocytic vesicle membrane]
Inferred From
AP2S1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000042753
Ensembl
ENSCAFT00000064628
,
ENSCAFP00000057273
,
ENSCAFG00000004193
VGNC
37962
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