Reactome | SH3GL2 [cytosol]

SH3GL2 [cytosol]

Stable Identifier

R-CFA-182958

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SH3GL2, A0A8I3NRM5

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by EGFR (Canis familiaris)
    - EGFR downregulation (Canis familiaris)
      - Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - CBL-mediated ubiquitination of CIN85 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        Ub-CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - EGFR binds EPS15, EPN1, EPS15L1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - EGFR non-clathrin mediated endocytosis (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - EGFR phosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PTPN3 dephosphorylates EPS15 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - Sprouty sequesters CBL away from active EGFR (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - Negative regulation of MET activity (Canis familiaris)
      - CBL recruits CIN85:endophilin to ubiquitinated MET (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - Epsin family proteins bind ubiquitinated cargo (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        ubiquitinated cargo [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Canis familiaris)
        
        CIN85:endophilin [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
        
        SH3GLs [cytosol] (Canis familiaris)
        
        SH3GL2 dimer [cytosol] (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
  - trans-Golgi Network Vesicle Budding (Canis familiaris)
    - Golgi Associated Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Coat Assembly (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - trans-Golgi Network Vesicle Scission (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
    - Lysosome Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)
        
        SH3GL2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NRM5

Gene Names

SH3GL2

Reference Genes

ENSEMBL:ENSCAFG00845013834.1

UCSC:A0A8I3NRM5 SH3GL2

Other Identifiers

Cfa.3062.1.A1_at

CfaAffx.3255.1.S1_s_at

CfaAffx.3258.1.S1_at

GO:0001933

GO:0003013

GO:0005737

GO:0010629

GO:0016020

GO:0016191

GO:0042802

GO:0048471

GO:0098793

GO:0098978

GO:1905604

Participates

as an output of

as an input of

as a component of

SH3GL2 dimer [cytosol] (Canis familiaris)

Other forms of this molecule

SH3GL2 [Golgi membrane]

SH3GL2 [clathrin-coated endocytic vesicle membrane]

SH3GL2 [plasma membrane]

Inferred From

SH3GL2 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845019469, ENSCAFT00845024744

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