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PDGFA [extracellular region]
Stable Identifier
R-CFA-184199
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
PDGFA-1, A0A8I3NEF4
Locations in the PathwayBrowser
Expand all
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Exocytosis of platelet alpha granule contents (Canis familiaris)
Platelet alpha granule contents [extracellular region] (Canis familiaris)
PDGF dimer [extracellular region] (Canis familiaris)
PDGF AB heterodimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Autophosphorylation of PDGF alpha receptors (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Activated PLC gamma dissociates from the PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Activation of Src (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Crk binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
GRB2:SOS1 complex binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Grb7 binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Nck binds to the active PDGF receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PI3-kinase binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PLC-gamma binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
Phosphorylation of PLCgamma by PDGFR (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
SH2 domain of Src binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
SHP2 binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
STAT binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
p130Cas and C3G bind PDGFR bound Crk (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF binds to extracellular matrix proteins (Canis familiaris)
PDGF A and B chains with retention motif [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF A and B chains:ECM complex [extracellular region] (Canis familiaris)
PDGF A and B chains with retention motif [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF dimer binds two receptors simultaneously (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF:PDGF receptor dimer [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGF-AA clevage by Furin (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGFRs bind type I TKI (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Canis familiaris)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
PDGFA [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NEF4
Gene Names
PDGFA
Reference Genes
ENSEMBL:ENSCAFG00845009942.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845009942.1 PDGFA
Other Identifiers
491597
Cfa.16338.1.S1_s_at
CfaAffx.17452.1.S1_at
GO:0007165
GO:0008083
GO:0016020
GO:0023052
GO:0048018
GO:0051781
GO:0098772
Participates
as a component of
PDGF AB heterodimer [extracellular region] (Canis familiaris)
active PDGF-AA dimer [extracellular region] (Canis familiaris)
as a member of
PDGF A and B chains with retention motif [extracellular region] (Canis familiaris)
Other forms of this molecule
PDGFA [platelet alpha granule lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [endoplasmic reticulum lumen]
PDGFA [Golgi lumen]
PDGFA [Golgi membrane]
PDGFA [Golgi membrane]
PDGFA [extracellular region]
Inferred From
Active platelet-derived growth factor A chain isoforms [extracellular region]
(Homo sapiens)
PDGFA-1 [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000197461
Ensembl
ENSCAFP00845013602
,
ENSCAFT00845017477
,
ENSCAFG00845009942
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