Reactome | TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-CFA-1911531

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

TMED2, E2RGZ5

Locations in the PathwayBrowser

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Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        p24 dimers [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RGZ5

Gene Names

TMED2

Reference Genes

BioGPS Gene:100687986 TMED2

ENSEMBL:ENSCAFG00000007468

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000007468 TMED2

KEGG Gene (Canis lupus familiaris):100687986 TMED2

Monarch:100687986 TMED2

NCBI Gene:100687986 TMED2

Reference Transcript

RefSeq:XM_003433432.3 TMED2

Other Identifiers

100687986

CfaAffx.12074.1.S1_s_at

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006810

GO:0006886

GO:0006888

GO:0007030

GO:0008150

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0030134

GO:0031410

GO:0033116

GO:0043226

Participates

as a component of

TMED2 dimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

This entity regulates

Negatively

Mature NOTCH heterodimer traffics to the plasma membrane (Canis familiaris)

Other forms of this molecule

TMED2 [endoplasmic reticulum membrane]

TMED2 [transport vesicle]

TMED2 [Golgi membrane]

Inferred From

TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Cross References

RefSeq

XP_003433480.1

OpenTargets

ENSG00000086598

Ensembl

ENSCAFP00000011095, ENSCAFG00000007468, ENSCAFT00000011964

VGNC

57417