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MYD88 dimer [cytosol]
Stable Identifier
R-CFA-193932
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Hyperphosphorylated IRAK1 associates with TRAF6 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IRAK1 binds to MYD88 within the IL1R complex (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IRAK4 is activated by autophosphorylation (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IRAK4 phosphorylates IRAK1 (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IRAK4-activated IRAK1 autophosphorylates (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
TRAF6 binding leads to IRAK1:TRAF6 release (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
The Interleukin 1 receptor complex binds Tollip (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IRAK interacts with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
MYD88 dissociates (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
MYD88 dimer [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
MYD88 [cytosol]
(Canis familiaris)
Participates
as an output of
MYD88 dissociates (Canis familiaris)
as a component of
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Canis familiaris)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Canis familiaris)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Canis familiaris)
as an input of
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Canis familiaris)
Inferred From
MYD88 dimer [cytosol]
(Homo sapiens)
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