Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SQSTM1 [cytosol]
Stable Identifier
R-CFA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SQSTM1, A0A8I3N2A1
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 links damaged mitochondria to LC3 (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Pexophagy (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
SQSTM1 oligomerizes (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 oligomer [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
TRIM21 ubiquitinates SQSTM1 (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
p62:MEKK3 binds to TRAF6 (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRIF signals cell death from the nucleus (Canis familiaris)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 recruits an atypical PKC (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N2A1
Gene Names
SQSTM1
Reference Genes
ENSEMBL:ENSCAFG00845007599.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845007599.1 SQSTM1
Other Identifiers
481459
Cfa.17608.1.S1_s_at
CfaAffx.1495.1.S1_at
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0005080
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007032
GO:0008270
GO:0010508
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030163
GO:0030674
GO:0031397
GO:0031410
GO:0031625
GO:0034614
GO:0035255
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0061912
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0098780
GO:0140036
GO:1900273
GO:1903078
GO:1905719
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Canis familiaris)
SQSTM1 oligomerizes (Canis familiaris)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
as a component of
SQSTM1 oligomer [cytosol] (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
Other forms of this molecule
SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000161011
Ensembl
ENSCAFG00845007599
,
ENSCAFP00845010418
,
ENSCAFT00845013425
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text