Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SQSTM1 [cytosol]
Stable Identifier
R-CFA-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SQSTM1, A0A5F4DJB2
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 links damaged mitochondria to LC3 (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Pexophagy (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
SQSTM1 oligomerizes (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 oligomer [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
TRIM21 ubiquitinates SQSTM1 (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
p62:MEKK3 binds to TRAF6 (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signalling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NRIF signals cell death from the nucleus (Canis familiaris)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
Polyubiquitinated NRIF migrates to the nucleus (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p75NTR recruits signalling complexes (Canis familiaris)
IKK-beta is recruited (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
TRAF6 is auto-ubiquitinated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
p62 recruits an atypical PKC (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
SQSTM1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A5F4DJB2
Gene Names
SQSTM1
Reference Genes
ENSEMBL:ENSCAFG00000000360
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000000360 SQSTM1
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Canis familiaris)
SQSTM1 oligomerizes (Canis familiaris)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Canis familiaris)
p62 is recruited and forms a complex with TRAF6 (Canis familiaris)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Canis familiaris)
p62 binds ubiquitinated mitochondrial substrates (Canis familiaris)
as a component of
SQSTM1 oligomer [cytosol] (Canis familiaris)
MAP3K3:SQSTM1 [cytosol] (Canis familiaris)
Ubiquitinated NRIF:Sequestosome [cytosol] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Canis familiaris)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Canis familiaris)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Canis familiaris)
Other forms of this molecule
SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
phospho-SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000161011
VGNC
46787
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
