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YWHAE [cytosol]
Stable Identifier
R-CFA-194368
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
YWHAE, A0A8I3NMG3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA damage checkpoint (Canis familiaris)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Canis familiaris)
Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Prometaphase (Canis familiaris)
Recruitment of NuMA to mitotic centrosomes (Canis familiaris)
Association of NuMA with microtubules (Canis familiaris)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Canis familiaris)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Canis familiaris)
Mature centrosome:nucleated microtubules [cytosol] (Canis familiaris)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Translocation of NuMA to the centrosomes (Canis familiaris)
Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Canis familiaris)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
AURKA Activation by TPX2 (Canis familiaris)
TPX2 binds AURKA at centrosomes (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
TPX2 promotes AURKA autophosphorylation (Canis familiaris)
Centrosome:AURKA:TPX2:HMMR [cytosol] (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA:TPX2:HMMR [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome maturation (Canis familiaris)
Loss of proteins required for interphase microtubule organization from the centrosome (Canis familiaris)
Loss of C-Nap-1 from centrosomes (Canis familiaris)
cNAP-1 depleted centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Loss of Nlp from mitotic centrosomes (Canis familiaris)
Dissociation of Phospho-Nlp from the centrosome (Canis familiaris)
Nlp-depleted centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome containing phosphorylated Nlp [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Plk1-mediated phosphorylation of Nlp (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome containing phosphorylated Nlp [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Recruitment of mitotic centrosome proteins and complexes (Canis familiaris)
Recruitment of CDK11p58 to the centrosomes (Canis familiaris)
Centrosomes containing recruited CDK11p58 [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Recruitment of Plk1 to centrosomes (Canis familiaris)
Centrosome associated Plk1 [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Canis familiaris)
Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Regulation of PLK1 Activity at G2/M Transition (Canis familiaris)
AJUBA binds centrosome-associated AURKA (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:AURKA:AJUBA [cytosol] (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
AJUBA facilitates AURKA autophosphorylation (Canis familiaris)
Centrosome:AURKA:AJUBA [cytosol] (Canis familiaris)
Centrosome:AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
AURKA phosphorylates PLK1 (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
BORA binds PLK1 and AURKA (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Canis familiaris)
Centrosome:p-T288-AURKA [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to heat stress (Canis familiaris)
HSF1 activation (Canis familiaris)
HSF1 trimer translocates to the nucleus (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
p-S303,307-HSF1 binds YWHAE (14-3-3) (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-S303,307-HSF1:YWHAE [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
TP53 Regulates Metabolic Genes (Canis familiaris)
DDIT4 binds 14-3-3 dimer (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
DDIT4:14-3-3 dimer [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
DDIT4:14-3-3 dimer [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-S939,T1462-TSC2:14-3-3 dimer [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Organelle biogenesis and maintenance (Canis familiaris)
Cilium Assembly (Canis familiaris)
Anchoring of the basal body to the plasma membrane (Canis familiaris)
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
C2CD3 binds the mother centriole (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Canis familiaris)
basal body:transition zone proteins [cytosol] (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
basal body:transition zone proteins [cytosol] (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
CP110 and CEP97 dissociate from the centriole (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
MARK4 binds ODF2 in the centriole (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
RAB3IP stimulates nucleotide exchange on RAB8A (Canis familiaris)
basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Canis familiaris)
basal body:transition zone proteins [cytosol] (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Recruitment of transition zone proteins (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
basal body:transition zone proteins [cytosol] (Canis familiaris)
basal body [cytosol] (Canis familiaris)
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
The distal appendage proteins recruit TTBK2 (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Canis familiaris)
Centrosome:C2CD3:distal appendage proteins [cytosol] (Canis familiaris)
mother centriole:C2CD3 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation of BH3-only proteins (Canis familiaris)
Activation of BAD and translocation to mitochondria (Canis familiaris)
Activation of BAD by calcineurin (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Sequestration of BAD protein by 14-3-3 (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
14-3-3 proteins:p-S99-BAD complex [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
Cell death signalling via NRAGE, NRIF and NADE (Canis familiaris)
NADE modulates death signalling (Canis familiaris)
14-3-3epsilon attentuates NADE-related apoptosis (Canis familiaris)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Signaling by Hippo (Canis familiaris)
YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ) (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-WWTR1:YWHAE [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases activate PKNs (Canis familiaris)
Association of p-S216-CDC25C with 14-3-3 proteins (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-S216-CDC25C:14-3-3 protein complex [cytosol] (Canis familiaris)
14-3-3 dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Rab regulation of trafficking (Canis familiaris)
RAB GEFs exchange GTP for GDP on RABs (Canis familiaris)
DENND1s exchange GTP for GDP on RAB35 (Canis familiaris)
RAB35 GEFs [cytosol] (Canis familiaris)
p-2S-DENND1A,B:YWHAE dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
YWHAE dimer binds phosphorylated DENND1 proteins (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
p-2S-DENND1A,B:YWHAE dimer [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
YWHAE [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NMG3
Gene Names
YWHAE
Reference Genes
BioGPS Gene:480645 YWHAE
ENSEMBL:ENSCAFG00845014071.1
Monarch:480645 YWHAE
NCBI Gene:480645 YWHAE
UCSC:A0A8I3NMG3 YWHAE
Reference Transcript
RefSeq:XM_849265.3 YWHAE
Other Identifiers
Cfa.19484.2.S1_s_at
Cfa.4461.1.S1_at
CfaAffx.21320.1.S1_s_at
GO:0005737
GO:0007165
GO:0007346
GO:0050815
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Canis familiaris)
mother centriole [cytosol] (Canis familiaris)
Nlp-depleted centrosome [cytosol] (Canis familiaris)
centrosome containing phosphorylated Nlp [cytosol] (Canis familiaris)
cNAP-1 depleted centrosome [cytosol] (Canis familiaris)
YWHAE dimer [cytosol] (Canis familiaris)
centrosome [cytosol] (Canis familiaris)
Inferred From
YWHAE [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_854358.1
ENSEMBL
ENSCAFT00845025159
,
ENSCAFP00845019789
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