Reactome | IL6R [plasma membrane]

IL6R [plasma membrane]

Stable Identifier

R-CFA-197824

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

IL6R, A0A8I3NUE0

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-6 family signaling (Canis familiaris)
      - Interleukin-6 signaling (Canis familiaris)
        
        Assembly of hexameric IL-6 receptor (Canis familiaris)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Canis familiaris)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6 binds IL6R (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6R:IL6R inhibitors [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6R binds IL6R inhibitors (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6R:IL6R inhibitors [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6ST is tyrosine phosphorylated (Canis familiaris)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        JAK activation (Canis familiaris)
        
        IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6 receptor trimer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        IL6 receptor hexamer:JAKs [plasma membrane] (Canis familiaris)
        
        IL6 receptor trimer:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        PTPN11 binds CBL (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        PTPN11 binds p-Y759-IL6ST (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        PTPN11 is phosphorylated (Canis familiaris)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Phosphorylated STATs are released (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        SOCS3 binds IL6ST (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Serine phosphorylation of STATs (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF-independent MAPK1/3 activation (Canis familiaris)
      - MAPK1 (ERK2) activation (Canis familiaris)
        
        MAP2K2 binds MAPK1 (Canis familiaris)
        
        IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
        
        Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Canis familiaris)
        
        IL6:IL6R [plasma membrane] (Canis familiaris)
        
        IL6R [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NUE0

Gene Names

IL6R

Reference Genes

BioGPS Gene:612271 IL6R

ENSEMBL:ENSCAFG00845014397.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014397.1 IL6R

Monarch:612271 IL6R

NCBI Gene:612271 IL6R

Reference Transcript

RefSeq:XM_850012.3 IL6R

Other Identifiers

612271

Cfa.12995.1.S1_at

Cfa.2779.1.A1_at

CfaAffx.26287.1.S1_s_at

GO:0002376

GO:0004896

GO:0004897

GO:0004915

GO:0005138

GO:0005515

GO:0005576

GO:0005886

GO:0005896

GO:0008284

GO:0010573

GO:0016020

GO:0016324

GO:0019221

GO:0019899

GO:0019981

GO:0023052

GO:0030154

GO:0031018

GO:0032722

GO:0032755

GO:0034097

GO:0036211

GO:0042531

GO:0042803

GO:0048661

GO:0048856

GO:0050731

GO:0060089

GO:0070102

GO:0070110

GO:0070119

GO:0070120

GO:0072126

GO:0072540

Participates

as an input of

as a component of

Other forms of this molecule

IL6R [extracellular region]

Inferred From

IL6R [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_855105.1

OpenTargets

ENSG00000160712

Ensembl

ENSCAFT00845025805, ENSCAFP00845020331, ENSCAFG00845014397

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