Reactome | CD40LG [plasma membrane]

CD40LG [plasma membrane]

Stable Identifier

R-CFA-198113

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CD40LG(1-261), O97626

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Canis familiaris)
    - CD40L binds CD40 (Canis familiaris)
      - CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
      - CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
- Cytokine Signaling in Immune system (Canis familiaris)
  - TNFR2 non-canonical NF-kB pathway (Canis familiaris)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
    - Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
      - CD40L binds CD40 (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Canis familiaris)
        
        CD40:CD40L trimer [plasma membrane] (Canis familiaris)
        
        CD40LG trimer [plasma membrane] (Canis familiaris)
        
        CD40LG [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:O97626

Gene Names

CD40LG

Reference Genes

BioGPS Gene:403468 CD40LG

ENSEMBL:ENSCAFG00845029290

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018945.5 CD40LG

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030017860.1 CD40LG

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040008883.1 CD40LG

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805019815 CD40LG

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029290.1 CD40LG

KEGG Gene (Canis lupus familiaris):403468 CD40LG

Monarch:403468 CD40LG

NCBI Gene:403468 CD40LG

Reference Transcript

RefSeq:NM_001002981.1 CD40LG

Other Identifiers

403468

Cfa.179.1.S1_s_at

Cfa.179.1.S2_s_at

GO:0002376

GO:0002637

GO:0005164

GO:0005174

GO:0005178

GO:0005515

GO:0005794

GO:0005886

GO:0006310

GO:0006954

GO:0006955

GO:0007155

GO:0007229

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0023035

GO:0023052

GO:0030154

GO:0030168

GO:0030183

GO:0032733

GO:0032735

GO:0032753

GO:0042060

GO:0042100

GO:0042102

GO:0043066

GO:0043226

GO:0043539

GO:0045190

GO:0048856

GO:0098772

GO:2000353

Participates

as a component of

CD40LG trimer [plasma membrane] (Canis familiaris)

Inferred From

CD40LG(1-261) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001002981.1

OpenTargets

ENSG00000102245

Ensembl

ENSCAFT00845051855, ENSCAFP00845040687, ENSCAFG00845029290

VGNC

38959

Cite Us!