DAG stimulates protein kinase C-delta

Stable Identifier
R-CFA-198314
Type
Reaction [transition]
Species
Canis familiaris
Compartment
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This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Participants
Participates
Catalyst Activity

protein kinase C activity of PKC-delta/epsilon [cytosol]

This event is regulated
Positively by
Regulator
Summation

Netrin-1, through its activation of DCC, triggers TRPC channel mediating the Ca+2 influx that is required for the growth cone turning. The effect of netrin-1 on TRP currents in the neurons is studied in Xenopus. In cultured Xenopus spinal neurons, Netrin-1 evoked Ca+2 influx and a depolarizing, TRPC-like current in both soma and growth cones. Inhibition of the Xenopus homologue of mammalian TRPC1 (XTRPC1) prevented Ca+2 influx, TRPC-like current activation and the chemotropic turning of the growth cone in response to a gradient of Netrin-1.
Netrin-1 receptor signalling to TRPC channels is mediated via hydrolysis of PIP2 by PLCgamma which then activates TRPC channel activity through IP3 and DAG.

Inferred From
Created
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