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PI3K alpha [cytosol]
Stable Identifier
R-CFA-198379
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K binds ICOS (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL ubiquitinates PI3K (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
G alpha (q) inhibits PI3K alpha (Canis familiaris)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PI3K binds membrane-associated estrogen receptors (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PTK2 is recruited to methylated ESR1 (Canis familiaris)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Direct recruitment of PI3K to p-KIT (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 binds effectors at the plasma membrane (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-regulatory subunits [cytosol]
(Canis familiaris)
PIK3CA [cytosol]
(Canis familiaris)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha, beta, gamma [cytosol] (Canis familiaris)
as an input of
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
PI3K binds membrane-associated estrogen receptors (Canis familiaris)
G alpha (q) inhibits PI3K alpha (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
PI3K binds ICOS (Canis familiaris)
Direct recruitment of PI3K to p-KIT (Canis familiaris)
as a component of
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
Inferred From
PI3K alpha [cytosol]
(Homo sapiens)
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