Reactome | NCKAP1 [cytosol]

NCKAP1 [cytosol]

Stable Identifier

R-CFA-200979

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NCKAP1, A0A8I3NZ88

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
      - ABL phosphorylates WAVEs (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        WAVE Regulatory Complex [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
      - p-ERK phosphorylates WAVEs and ABI (Canis familiaris)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Canis familiaris)
        
        p-Y,S,T-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Canis familiaris)
        
        p-Y-WRC [cytosol] (Canis familiaris)
        
        NCKAP1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NZ88

Gene Names

NCKAP1

Reference Genes

BioGPS Gene:478828 NCKAP1

ENSEMBL:ENSCAFG00845016102.1

Monarch:478828 NCKAP1

NCBI Gene:478828 NCKAP1

UCSC:A0A8I3NZ88 NCKAP1

Reference Transcript

Other Identifiers

478828

Cfa.19712.1.S1_s_at

Cfa.560.1.S1_at

CfaAffx.22232.1.S1_s_at

GO:0001701

GO:0001726

GO:0001756

GO:0001843

GO:0007010

GO:0007163

GO:0007354

GO:0007492

GO:0008078

GO:0010172

GO:0010592

GO:0016601

GO:0030027

GO:0030032

GO:0030838

GO:0030903

GO:0030950

GO:0031209

GO:0031267

GO:0031941

GO:0032880

GO:0035050

GO:0042074

GO:0045175

GO:0045176

GO:0048339

GO:0048340

GO:0048570

GO:0048617

GO:0048856

GO:0048870

GO:0050821

GO:0098794

GO:2000601

Participates

as a candidate of

RAC2 plasma membrane effectors [cytosol] (Canis familiaris)

as a component of

Inferred From

NCKAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038440975.1, XP_038303191.1, XP_038319211.1

ENSEMBL

ENSCAFP00845022577, ENSCAFT00845028685, ENSCAFG00845016102

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