Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PTN [extracellular region]
Stable Identifier
R-CFA-201500
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
PTN, A0A8I3RUQ5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
ALK autophosphorylation (Canis familiaris)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK binds JAK3 (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK binds PLCG1 (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK binds SHC1 (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:SHC1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK dimer binds IRS1 (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:IRS1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK phosphorylates IRS1 (Canis familiaris)
Active ALK:IRS1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:pY-IRS1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK phosphorylates JAK3 (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:p-Y980 JAK3 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK phosphorylates PLCG1 (Canis familiaris)
Active ALK:PLCG1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:p-4Y PLCG1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK phosphorylates SHC1 (Canis familiaris)
Active ALK:SHC1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:p-3Y SHC1 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK recruits PI3K (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
ligand-bound ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
MDK and PTN in ALK signaling (Canis familiaris)
(PTN,MDK):PTPRZ oligomerizes (Canis familiaris)
(PTN,MDK):PTPRZ [plasma membrane] (Canis familiaris)
PTN,MDK [extracellular region] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Canis familiaris)
(PTN,MDK):PTPRZ [plasma membrane] (Canis familiaris)
PTN,MDK [extracellular region] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
ALK binds ligand pleiotrophin (PTN) (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PTN:ALK [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PTN and MDK bind to PTPRZ (Canis familiaris)
(PTN,MDK):PTPRZ [plasma membrane] (Canis familiaris)
PTN,MDK [extracellular region] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PTN,MDK [extracellular region] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PTPRZ dephosphorylates ligand-bound ALK dimers (Canis familiaris)
(PTN,MDK):ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
(PTN,MDK):PTPRZ oligomers [plasma membrane] (Canis familiaris)
(PTN,MDK):PTPRZ [plasma membrane] (Canis familiaris)
PTN,MDK [extracellular region] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
(PTN,MDK):p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
PTPN6 dephosphorylates JAK3 (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
Active ALK:p-Y980 JAK3 [plasma membrane] (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
STAT3 is phosphorylated downstream of active ALK (Canis familiaris)
Active ALK dimer [plasma membrane] (Canis familiaris)
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3RUQ5
Gene Names
PTN
Reference Genes
ENSEMBL:ENSCAFG00845008663.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845008663.1 PTN
Other Identifiers
475509
CfaAffx.5983.1.S1_at
CfaAffx.5983.1.S1_s_at
GO:0005576
GO:0007165
GO:0008083
GO:0008201
GO:0016020
GO:0023052
GO:0048018
GO:0050896
GO:0051781
GO:0098772
Participates
as a member of
PTN,MDK [extracellular region] (Canis familiaris)
as a component of
PTN:p-7Y ALK dimer [plasma membrane] (Canis familiaris)
PTN:ALK [plasma membrane] (Canis familiaris)
PTN:ALK dimer [plasma membrane] (Canis familiaris)
as an input of
ALK binds ligand pleiotrophin (PTN) (Canis familiaris)
Inferred From
PTN [extracellular region]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000105894
Ensembl
ENSCAFG00845008663
,
ENSCAFP00845011840
,
ENSCAFT00845015247
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text