Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PRKN [cytosol]
Stable Identifier
R-CFA-201579
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PRKN, A0A8I3MGN8
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Aggrephagy (Canis familiaris)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Canis familiaris)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Parkin transfers Ub to misfolded proteins (Canis familiaris)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Mitophagy (Canis familiaris)
PINK1-PRKN Mediated Mitophagy (Canis familiaris)
PINK1 phosphorylates PRKN at S65 (Canis familiaris)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
PRKN binds p-S-Ub:MOM proteins (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Josephin domain DUBs (Canis familiaris)
ATXN3 deubiquitinates polyUb-PARK2 (Canis familiaris)
ATXN3:PARK2 [cytosol] (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
PARK2 autoubiquitinates (Canis familiaris)
PRKN [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MGN8
Gene Names
PRKN
Reference Genes
BioGPS Gene:612316 PRKN
ENSEMBL:ENSCAFG00845002459.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002459.1 PRKN
KEGG Gene (Canis lupus familiaris):612316 PRKN
Monarch:612316 PRKN
NCBI Gene:612316 PRKN
Reference Transcript
RefSeq:XM_850059.4 PRKN
Other Identifiers
612316
CfaAffx.2074.1.S1_at
GO:0000122
GO:0000151
GO:0000209
GO:0000422
GO:0000423
GO:0001664
GO:0001933
GO:0001963
GO:0001964
GO:0003714
GO:0003779
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006914
GO:0007005
GO:0007010
GO:0007612
GO:0007626
GO:0008013
GO:0008092
GO:0008270
GO:0008344
GO:0010498
GO:0010506
GO:0010628
GO:0010629
GO:0010636
GO:0010821
GO:0010994
GO:0012501
GO:0015631
GO:0016192
GO:0016235
GO:0016567
GO:0016607
GO:0016740
GO:0019538
GO:0019899
GO:0019900
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030165
GO:0030544
GO:0031072
GO:0031396
GO:0031410
GO:0031624
GO:0031625
GO:0031647
GO:0031648
GO:0032232
GO:0032436
GO:0032991
GO:0034976
GO:0035249
GO:0036211
GO:0042053
GO:0042415
GO:0042417
GO:0042802
GO:0042826
GO:0043005
GO:0043123
GO:0043130
GO:0043161
GO:0043226
GO:0043274
GO:0043524
GO:0044828
GO:0044877
GO:0045944
GO:0046676
GO:0046872
GO:0046928
GO:0048471
GO:0048856
GO:0050804
GO:0050821
GO:0050877
GO:0051087
GO:0051582
GO:0051583
GO:0051865
GO:0051881
GO:0061024
GO:0061630
GO:0061734
GO:0065003
GO:0070534
GO:0070585
GO:0070842
GO:0070936
GO:0070979
GO:0085020
GO:0090090
GO:0090201
GO:0097237
GO:0097602
GO:0098691
GO:0098779
GO:0098793
GO:0099073
GO:0099074
GO:0140096
GO:0140110
GO:0140251
GO:1900242
GO:1900407
GO:1901800
GO:1902236
GO:1902254
GO:1902530
GO:1903265
GO:1903377
GO:1903382
GO:1903542
GO:1903599
GO:1903861
GO:1904049
GO:1905366
GO:1905477
GO:1990381
GO:1990444
GO:1990452
GO:2000377
GO:2000378
Participates
as a component of
ATXN3:PARK2 [cytosol] (Canis familiaris)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Canis familiaris)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
UBE2N:UBE2V1:PRKN [cytosol] (Canis familiaris)
as an input of
PARK2 autoubiquitinates (Canis familiaris)
PRKN binds p-S-Ub:MOM proteins (Canis familiaris)
Parkin binds Ub:UBE2N:UBE2V1 (Canis familiaris)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
Other forms of this molecule
PRKN [cytosol]
phospho-PRKN [cytosol]
phospho-PRKN [cytosol]
Inferred From
PRKN [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_855152.2
OpenTargets
ENSG00000185345
Ensembl
ENSCAFG00845002459
,
ENSCAFT00845004490
,
ENSCAFP00845003590
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text