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WASL [cytosol]
Stable Identifier
R-CFA-201873
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
N-WASP, A0A8I3N1W7
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Canis familiaris)
Nephrin family interactions (Canis familiaris)
Nephrin mediated activation of N-WASP (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
EPHB-mediated forward signaling (Canis familiaris)
CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
ITSN1:N-WASP [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
ITSN1:N-WASP [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
N-WASP binds ARP2/3 and G-actin (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
ITSN1:N-WASP [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
ITSN1:N-WASP [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of nitric oxide: NOS3 activation and regulation (Canis familiaris)
NOSTRIN mediated eNOS trafficking (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase Effectors (Canis familiaris)
RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
Src phosphorylate WASP,N-WASP (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
WIP binds WASP,N-WASP, activating them (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 binds effectors at the plasma membrane (Canis familiaris)
CDC42 effectors [cytosol] (Canis familiaris)
WIP:WASP complex [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
CDC42:GTP:CDC42 effectors [plasma membrane] (Canis familiaris)
CDC42 effectors [cytosol] (Canis familiaris)
WIP:WASP complex [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
WIP:WASP complex [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
WIP:WASP complex [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Membrane Trafficking (Canis familiaris)
Clathrin-mediated endocytosis (Canis familiaris)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
BAR domain proteins recruit dynamin (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WASL [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N1W7
Gene Names
WASL
Reference Genes
ENSEMBL:ENSCAFG00845006059.1
UCSC:A0A8I3N1W7 WASL
Other Identifiers
475213
Cfa.20419.1.A1_s_at
CfaAffx.3560.1.S1_s_at
GO:0003779
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0006355
GO:0007010
GO:0007015
GO:0008092
GO:0009617
GO:0030027
GO:0030036
GO:0030041
GO:0030478
GO:0031503
GO:0032880
GO:0043226
GO:0045944
GO:0051653
GO:0060997
GO:0065003
GO:0098978
GO:0099175
GO:1903526
GO:2000402
Participates
as a component of
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
WIP:WASP complex [cytosol] (Canis familiaris)
ITSN1:N-WASP [cytosol] (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Canis familiaris)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
as an input of
SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
Nephrin mediated activation of N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
Other forms of this molecule
WASL [endocytic vesicle membrane]
WASL [plasma membrane]
phospho-WASL [cytosol]
Inferred From
WASL,CTTN [cytosol]
(Homo sapiens)
WASP/N-WASP [cytosol]
(Homo sapiens)
N-WASP [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845008437
,
ENSCAFT00845010812
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