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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Diseases
Cytomics
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phospho-IKBKB [cytosol]
Stable Identifier
R-CFA-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S177,S181-IKBKB, A0A8I3N4F2
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
Activation of IKK complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Interleukin-17 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
Phosphorylation of IKK-beta by TAK1 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of NEMO by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
MAP kinase activation (Canis familiaris)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Canis familiaris)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate CYLD at S418 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta is activated (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
Phospho-IKK-beta homdimer [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Canis familiaris)
Phospho-IKK-beta homdimer [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
Phospho-IKK-beta homdimer [cytosol] (Canis familiaris)
phospho-IKBKB [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N4F2
Gene Names
IKBKB
Reference Genes
BioGPS Gene:482839 IKBKB
ENSEMBL:ENSCAFG00845006197.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006197.1 IKBKB
Monarch:482839 IKBKB
NCBI Gene:482839 IKBKB
Reference Transcript
RefSeq:XM_539954.5 IKBKB
RefSeq:XM_014120062.1 IKBKB
Other Identifiers
482839
Cfa.8326.1.A1_at
CfaAffx.9249.1.S1_at
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007249
GO:0008384
GO:0016740
GO:0019901
GO:0023052
GO:0030154
GO:0030866
GO:0033209
GO:0034330
GO:0036211
GO:0042325
GO:0042802
GO:0042803
GO:0043123
GO:0045944
GO:0046982
GO:0048856
GO:0051604
GO:0070498
GO:0071356
GO:0072659
GO:0097110
GO:0140096
GO:1903140
GO:1903347
GO:1990459
Participates
as a component of
Phospho-IKK-beta homdimer [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:pUb-IKBKG [cytosol] (Canis familiaris)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Canis familiaris)
CHUK:p-S177,S181-IKBKB:IKBKG [cytosol] (Canis familiaris)
Other forms of this molecule
IKBKB [cytosol]
Inferred From
p-S177,S181-IKBKB [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 177 (in Homo sapiens)
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 181 (in Homo sapiens)
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_539954.2
,
XP_013975537.1
OpenTargets
ENSG00000104365
Ensembl
ENSCAFG00845006197
,
ENSCAFT00845011002
,
ENSCAFP00845008588
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