Reactome | DCTN4 [cytosol]

DCTN4 [cytosol]

Stable Identifier

R-CFA-2029070

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

DCTN4, A0A8I3N2P7

Locations in the PathwayBrowser

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Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
      - Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - MHC class II antigen presentation (Canis familiaris)
    - Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
      - Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
      - Kinesins:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        Dynein:Dynactin:microtubule [cytosol] (Canis familiaris)
        
        Dynactin [cytosol] (Canis familiaris)
        
        Dynactin rod [cytosol] (Canis familiaris)
        
        ACTR10:DCTN4:DCTN5:DCTN6 [cytosol] (Canis familiaris)
        
        Pointed end complex [cytosol] (Canis familiaris)
        
        DCTN4 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N2P7

Gene Names

DCTN4

Reference Genes

BioGPS Gene:479326 DCTN4

ENSEMBL:ENSCAFG00845006343.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006343.1 DCTN4

KEGG Gene (Canis lupus familiaris):479326 DCTN4

Monarch:479326 DCTN4

NCBI Gene:479326 DCTN4

Reference Transcript

RefSeq:XM_848442.4 DCTN4

Other Identifiers

479326

Cfa.13086.1.S1_at

Cfa.17761.1.S1_s_at

CfaAffx.27695.1.S1_at

CfaAffx.27695.1.S1_s_at

GO:0005813

GO:0005815

GO:0005856

GO:0005869

GO:0043226

Participates

as a component of

Pointed end complex [cytosol] (Canis familiaris)

Inferred From

DCTN4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_853535.1

OpenTargets

ENSG00000132912

Ensembl

ENSCAFG00845006343, ENSCAFP00845008798, ENSCAFT00845011279

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