Reactome | DSG1 [plasma membrane]

DSG1 [plasma membrane]

Stable Identifier

R-CFA-202912

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

DSG1, A0A8I3NIB1

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Keratinization (Canis familiaris)
  - Formation of the cornified envelope (Canis familiaris)
    - CASP14 cleaves filaggrin (Canis familiaris)
      - Late cornified envelope [plasma membrane] (Canis familiaris)
        
        Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - CDSN binds the cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - Cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - Fillagrin and keratin intermediate filaments polymerize forming a network (Canis familiaris)
      - FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - Lamellar bodies bind the early cornified envelope (Canis familiaris)
      - Cornified envelope [plasma membrane] (Canis familiaris)
        
        Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - Early cornified envelope [plasma membrane] (Canis familiaris)
        
        FLG-Keratin filament network [plasma membrane] (Canis familiaris)
        
        FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - PERP binds desmosomes (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
      - Desmosome:PERP [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - Plasma membrane resorption (Canis familiaris)
      - Mature cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Canis familiaris)
        
        No FGN-Cornified envelope [plasma membrane] (Canis familiaris)
        
        No FGN-late cornified envelope [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome network [plasma membrane] (Canis familiaris)
        
        Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
        
        Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
  - Keratin filaments bind cell-cell adhesion complexes (Canis familiaris)
    - Desmosome [plasma membrane] (Canis familiaris)
      - Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)
    - Keratin tonofilament:Desmosome [plasma membrane] (Canis familiaris)
      - Desmosome [plasma membrane] (Canis familiaris)
        
        Desmogelins [plasma membrane] (Canis familiaris)
        
        DSG1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NIB1

Gene Names

DSG1

Reference Genes

ENSEMBL:ENSCAFG00845011100.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011100.1 DSG1

Other Identifiers

403401

CfaAffx.27670.1.S1_s_at

GO:0005509

GO:0005634

GO:0005737

GO:0005886

GO:0005911

GO:0007155

GO:0007156

GO:0009898

GO:0016020

GO:0030057

GO:0043226

GO:0045295

GO:0050821

GO:0070161

Participates

as a candidate of

as a member of

as an input of

Caspase-mediated cleavage of Desmoglein 1 (Canis familiaris)

Other forms of this molecule

DSG1 [cornified envelope]

DSG1 [ficolin-1-rich granule membrane]

DSG1 [cytosol]

DSG1 [plasma membrane]

Inferred From

DSG1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000134760

Ensembl

ENSCAFT00845019678, ENSCAFP00845015394, ENSCAFG00845011100

Cite Us!