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NCK2 [cytosol]
Stable Identifier
R-CFA-204885
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
NCK2, A0A8I3N1K5
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Canis familiaris)
Nephrin family interactions (Canis familiaris)
Nephrin binds NCK (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
Nephrin mediated activation of N-WASP (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Canis familiaris)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
EPH-Ephrin signaling (Canis familiaris)
Ephrin signaling (Canis familiaris)
EFNB:GRB4 binds GIT1 (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
GIT1 binds bPIX (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PAK binds RAC and bPIX (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PAKs autophosphorylate (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PAKs phosphorylate MLC (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
p-EFNB binds GRB4 (Canis familiaris)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
Nck binds to the active PDGF receptor (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
CDC42:GTP binds PAK2 (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
FYN autophosphorylates (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
FYN phosphorylates PAK2 (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PAK2 autophorylates (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
PAK2 binds NCK (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
p-6Y-VEGFR2 binds FYN (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
p-6Y-VEGFR2 binds NCK (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
p-Y420-FYN is phosphorylated on S21 (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
p38 MAPK activation by VEGFR (Canis familiaris)
VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RHOU GTPase cycle (Canis familiaris)
RHOU binds effectors at the plasma membrane (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
RHOV GTPase cycle (Canis familiaris)
RHOV binds effectors at the plasma membrane (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
RHOV:GTP:RHOV effectors [plasma membrane] (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
NCK2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N1K5
Gene Names
NCK2
Reference Genes
BioGPS Gene:481319 NCK2
ENSEMBL:ENSCAFG00845009565.1
KEGG:cfa:481319 NCK2
Monarch:481319 NCK2
NCBI Gene:481319 NCK2
UCSC:A0A8I3N1K5 NCK2
Reference Transcript
RefSeq:XM_005625986.2 NCK2
RefSeq:XM_005625985.2 NCK2
RefSeq:XM_014117410.1 NCK2
RefSeq:XM_005625984.2 NCK2
Other Identifiers
481319
CfaAffx.4066.1.S1_at
GO:0000122
GO:0001784
GO:0005737
GO:0005783
GO:0005829
GO:0006355
GO:0006417
GO:0007015
GO:0007165
GO:0012506
GO:0016477
GO:0030032
GO:0030838
GO:0030971
GO:0034976
GO:0035591
GO:0036493
GO:0042102
GO:0043226
GO:0044877
GO:0045944
GO:0048013
GO:0048870
GO:0060090
GO:0097110
GO:1902237
GO:1902310
GO:1903898
GO:1903912
Participates
as a candidate of
RHOV effectors [cytosol] (Canis familiaris)
as a member of
RHOU effectors [cytosol] (Canis familiaris)
NCK1,NCK2 [cytosol] (Canis familiaris)
as an input of
p-EFNB binds GRB4 (Canis familiaris)
as a component of
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
Inferred From
NCK2 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845016842
,
ENSCAFP00845013099
,
ENSCAFG00845009565
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