Reactome | NCK2 [cytosol]

NCK2 [cytosol]

Stable Identifier

R-CFA-204885

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NCK2, E2RPY6

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - Ephrin signaling (Canis familiaris)
        
        EFNB:GRB4 binds GIT1 (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        GIT1 binds bPIX (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        PAK binds RAC and bPIX (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        PAKs autophosphorylate (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        PAKs phosphorylate MLC (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        p-EFNB binds GRB4 (Canis familiaris)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by PDGF (Canis familiaris)
    - Downstream signal transduction (Canis familiaris)
      - Nck binds to the active PDGF receptor (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
  - Signaling by VEGF (Canis familiaris)
    - VEGFA-VEGFR2 Pathway (Canis familiaris)
      - CDC42:GTP binds PAK2 (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - FYN autophosphorylates (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - FYN phosphorylates PAK2 (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - PAK2 autophorylates (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - PAK2 binds NCK (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - p-6Y-VEGFR2 binds FYN (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - p-6Y-VEGFR2 binds NCK (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - p-Y420-FYN is phosphorylated on S21 (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - p38 MAPK activation by VEGFR (Canis familiaris)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Canis familiaris)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Canis familiaris)
        
        NCK1,NCK2 [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase cycle (Canis familiaris)
      - RHOU GTPase cycle (Canis familiaris)
        
        RHOU binds effectors at the plasma membrane (Canis familiaris)
        
        RHOU effectors [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
        
        RHOU effectors [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
      - RHOV GTPase cycle (Canis familiaris)
        
        RHOV binds effectors at the plasma membrane (Canis familiaris)
        
        RHOV effectors [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Canis familiaris)
        
        RHOV effectors [cytosol] (Canis familiaris)
        
        NCK2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RPY6

Gene Names

NCK2

Reference Genes

BioGPS Gene:481319 NCK2

ENSEMBL:ENSCAFG00000002099

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000002099 NCK2

KEGG Gene (Canis lupus familiaris):481319 NCK2

Monarch:481319 NCK2

NCBI Gene:481319 NCK2

Reference Transcript

Other Identifiers

481319

CfaAffx.4066.1.S1_at

GO:0001784

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005829

GO:0006412

GO:0006417

GO:0006464

GO:0006950

GO:0007010

GO:0007015

GO:0007155

GO:0007165

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0012506

GO:0016477

GO:0022607

GO:0030032

GO:0030838

GO:0033137

GO:0034641

GO:0036493

GO:0040011

GO:0042102

GO:0043226

GO:0044877

GO:0045944

GO:0048013

GO:0048870

GO:0065003

GO:0097110

GO:1902237

GO:1903898

GO:1903912

GO:1990441

Participates

as a candidate of

RHOV effectors [cytosol] (Canis familiaris)

as a member of

as an input of

p-EFNB binds GRB4 (Canis familiaris)

as a component of

EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Canis familiaris)

Inferred From

NCK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005626042.1, XP_013972885.1, XP_005626043.1, XP_005626041.1

OpenTargets

ENSG00000071051

Ensembl

ENSCAFG00000002099, ENSCAFT00000003324, ENSCAFP00000003087

VGNC

43652

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