Reactome | HDAC2 [nucleoplasm]

HDAC2 [nucleoplasm]

Stable Identifier

R-CFA-205135

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

HDAC2, A0A8I3S1X7

Locations in the PathwayBrowser

Expand all

Chromatin organization (Canis familiaris)

- Chromatin modifying enzymes (Canis familiaris)
  - HDACs deacetylate histones (Canis familiaris)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        BHC complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        CoREST complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        Sin3A complex [nucleoplasm] (Canis familiaris)
        
        Sin3a core complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        BHC complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        CoREST complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        Sin3A complex [nucleoplasm] (Canis familiaris)
        
        Sin3a core complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
    - HDAC1:2-containing complex deacetylate histones (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        BHC complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        CoREST complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        Sin3A complex [nucleoplasm] (Canis familiaris)
        
        Sin3a core complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        BHC complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        CoREST complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        Sin3A complex [nucleoplasm] (Canis familiaris)
        
        Sin3a core complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase I Transcription (Canis familiaris)
  - RNA Polymerase I Promoter Clearance (Canis familiaris)
    - RNA Polymerase I Transcription Initiation (Canis familiaris)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Notch-HLH transcription pathway (Canis familiaris)
      - Formation of CSL NCOR corepressor complex (Canis familiaris)
        
        HDAC [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Canis familiaris)
        
        HDAC [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
    - Transcriptional Regulation by MECP2 (Canis familiaris)
      - Regulation of MECP2 expression and activity (Canis familiaris)
        
        MECP2 binds the SIN3A co-repressor complex (Canis familiaris)
        
        MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Canis familiaris)
        
        MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        MECP2:SIN3A:HDAC2 [nucleoplasm] (Canis familiaris)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Canis familiaris)
        
        HDAC2 homodimer [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Canis familiaris)
        
        SIN3A:HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        SIN3A:HDAC2 homodimer [nucleoplasm] (Canis familiaris)
        
        HDAC2 homodimer [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - Regulation of TP53 Activity (Canis familiaris)
        
        Regulation of TP53 Activity through Acetylation (Canis familiaris)
        
        MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
        
        MTA2-NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)

Hemostasis (Canis familiaris)

- Factors involved in megakaryocyte development and platelet production (Canis familiaris)
  - REST recruits the BHC complex (Canis familiaris)
    - BHC complex [nucleoplasm] (Canis familiaris)
      - HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
    - BHC complex:REST:REST DNA binding sites [nucleoplasm] (Canis familiaris)
      - BHC complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        SALL4 recruits NuRD to PTEN gene (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        HDAC1:HDAC2 [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by ALK (Canis familiaris)
    - STAT3 nuclear events downstream of ALK signaling (Canis familiaris)
      - HDACs deacetylate p-STAT3 dimers (Canis familiaris)
        
        Histone deacetylase [nucleoplasm] (Canis familiaris)
        
        HDAC2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S1X7

Gene Names

HDAC2

Reference Genes

ENSEMBL:ENSCAFG00845020776.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020776.1 HDAC2

Other Identifiers

475035

Cfa.2864.1.A1_s_at

GO:0000118

GO:0000122

GO:0000228

GO:0000781

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008284

GO:0010944

GO:0016575

GO:0016580

GO:0016581

GO:0016787

GO:0019899

GO:0031507

GO:0032991

GO:0033558

GO:0035098

GO:0036211

GO:0042393

GO:0042826

GO:0043226

GO:0045862

GO:0045944

GO:0046872

GO:0051059

GO:0061629

GO:0070822

GO:0140096

GO:0160009

GO:0160010

Participates

as a component of

as a member of

Histone deacetylase [nucleoplasm] (Canis familiaris)

as a candidate of

HDAC [nucleoplasm] (Canis familiaris)

Inferred From

HDAC2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000196591

Ensembl

ENSCAFG00845020776, ENSCAFP00845028668, ENSCAFT00845036630

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