Reactome | CDK8 [nucleoplasm]

CDK8 [nucleoplasm]

Stable Identifier

R-CFA-212440

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

CDK8, E2RMV5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Canis familiaris)
        
        CDK8:CCNC [nucleoplasm] (Canis familiaris)
        
        CDK8 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by TGFB family members (Canis familiaris)
  - Signaling by TGF-beta Receptor Complex (Canis familiaris)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Canis familiaris)
        
        CDK8:CCNC [nucleoplasm] (Canis familiaris)
        
        CDK8 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RMV5

Gene Names

CDK8

Reference Genes

BioGPS Gene:486035 CDK8

ENSEMBL:ENSCAFG00000006870

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000006870 CDK8

Monarch:486035 CDK8

NCBI Gene:486035 CDK8

Reference Transcript

RefSeq:XM_844758.3 CDK8

Other Identifiers

486035

CfaAffx.11224.1.S1_at

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004693

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0006464

GO:0006468

GO:0007049

GO:0008150

GO:0008353

GO:0016301

GO:0016592

GO:0032991

GO:0043167

GO:0043226

GO:0051726

Participates

as a component of

CDK8:CCNC [nucleoplasm] (Canis familiaris)

Inferred From

CDK8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_849851.2

OpenTargets

ENSG00000132964

Ensembl

ENSCAFP00000010245, ENSCAFT00000011055, ENSCAFG00000006870

VGNC

39061

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