Reactome | LOC611538 [plasma membrane]

LOC611538 [plasma membrane]

Stable Identifier

R-CFA-2130735

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CLEC4E, A0A8I3PLZ5

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - C-type lectin receptors (CLRs) (Canis familiaris)
    - Dectin-2 family (Canis familiaris)
      - CLEC4E binds alpha-mannan and trehalose-6-6'-dimycolate (Canis familiaris)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)
        
        CLEC4E:FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
      - PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
      - SYK autophosphorylates (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
      - SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        LOC611538 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PLZ5

Gene Names

LOC611538

Reference Genes

BioGPS Gene:611538 LOC611538

ENSEMBL:ENSCAFG00845023026.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845023026.1 LOC611538

KEGG Gene (Canis lupus familiaris):611538 LOC611538

Monarch:611538 LOC611538

NCBI Gene:611538 LOC611538

Reference Transcript

RefSeq:XM_849218.4 LOC611538

Other Identifiers

611538

CfaAffx.21504.1.S1_s_at

GO:0001819

GO:0002292

GO:0002376

GO:0005886

GO:0006955

GO:0008289

GO:0023052

GO:0030154

GO:0030670

GO:0031410

GO:0038023

GO:0038094

GO:0038187

GO:0042742

GO:0043226

GO:0045087

GO:0048856

GO:0051861

GO:0060089

GO:0061760

GO:0098542

Participates

as a component of

Inferred From

CLEC4E [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_854311.1

Ensembl

ENSCAFG00845023026, ENSCAFP00845031809, ENSCAFT00845040637