Reactome | TGIF1 [nucleoplasm]

TGIF1 [nucleoplasm]

Stable Identifier

R-CFA-2186594

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

TGIF1, A0A8I3MRF1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
        
        TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
        
        TGIF [nucleoplasm] (Canis familiaris)
        
        TGIF1 [nucleoplasm] (Canis familiaris)
        
        p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Canis familiaris)
        
        TGIF [nucleoplasm] (Canis familiaris)
        
        TGIF1 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by TGFB family members (Canis familiaris)
  - Signaling by TGF-beta Receptor Complex (Canis familiaris)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Canis familiaris)
        
        TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
        
        TGIF [nucleoplasm] (Canis familiaris)
        
        TGIF1 [nucleoplasm] (Canis familiaris)
        
        p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Canis familiaris)
        
        TGIF [nucleoplasm] (Canis familiaris)
        
        TGIF1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MRF1

Gene Names

TGIF1

Reference Genes

BioGPS Gene:490537 TGIF1

ENSEMBL:ENSCAFG00845003025.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845003025.1 TGIF1

Monarch:490537 TGIF1

NCBI Gene:490537 TGIF1

Reference Transcript

Other Identifiers

490537

CfaAffx.18412.1.S1_s_at

GO:0000122

GO:0000978

GO:0001227

GO:0003677

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0043226

GO:0140110

GO:1990837

Participates

as a member of

TGIF [nucleoplasm] (Canis familiaris)

Inferred From

TGIF1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013971011.1, XP_547659.2

OpenTargets

ENSG00000177426

Ensembl

ENSCAFG00845003025, ENSCAFT00845005343, ENSCAFP00845004256

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