Reactome | NCKIPSD [cytosol]

NCKIPSD [cytosol]

Stable Identifier

R-CFA-2197671

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

NCKIPSD, A0A8I3Q9N2

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
      - Src phosphorylate WASP,N-WASP (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
      - WIP binds WASP,N-WASP, activating them (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
  - Signaling by Rho GTPases (Canis familiaris)
    - RHO GTPase Effectors (Canis familiaris)
      - RHO GTPases Activate WASPs and WAVEs (Canis familiaris)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        Src phosphorylate WASP,N-WASP (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        WIP binds WASP,N-WASP, activating them (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        NCKIPSD [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q9N2

Gene Names

NCKIPSD

Reference Genes

ENSEMBL:ENSCAFG00845030141.1

UCSC:A0A8I3Q9N2 NCKIPSD

Other Identifiers

484776

CfaAffx.18900.1.S1_at

GO:0008180

GO:0010976

Participates

as a member of

SH3 domain proteins [cytosol] (Canis familiaris)

Inferred From

NCKIPSD [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFT00845053452, ENSCAFP00845041998, ENSCAFG00845030141

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