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phospho-LAT [plasma membrane]
Stable Identifier
R-CFA-2396597
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
p-5Y-LAT-2, E2RB09
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
Activation of RAC1 by VAV2/3 (Canis familiaris)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Release of p-PLCG1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Autophosphorylation of BTK/ITK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
FCERI mediated MAPK activation (Canis familiaris)
Activation of RAC1 by VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Autophosphorylation of PAK (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Phosphorylation and activation of VAV (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Recruitment of VAV to p-SLP-76 (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Phosphorylation of LAT by p-SYK (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
phospho-LAT [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:E2RB09
Gene Names
LAT
Reference Genes
ENSEMBL:ENSCAFG00000017333
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000017333 LAT
Other Identifiers
607947
CfaAffx.26524.1.S1_s_at
GO:0001772
GO:0002376
GO:0003674
GO:0005575
GO:0005622
GO:0005737
GO:0005794
GO:0005886
GO:0006464
GO:0006955
GO:0007165
GO:0007229
GO:0007265
GO:0008150
GO:0016020
GO:0016021
GO:0019722
GO:0019899
GO:0019901
GO:0030159
GO:0030674
GO:0035556
GO:0043226
GO:0045860
GO:0050863
Participates
as an output of
Phosphorylation of LAT by p-SYK (Canis familiaris)
as an input of
Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
as a component of
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-LAT [plasma membrane]
LAT [plasma membrane]
phospho-LAT [plasma membrane]
Inferred From
p-5Y-LAT-2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 127 (in Homo sapiens)
Coordinate
127
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 132 (in Homo sapiens)
Coordinate
132
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 171 (in Homo sapiens)
Coordinate
171
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 191 (in Homo sapiens)
Coordinate
191
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000213658
Ensembl
ENSCAFP00000025545
,
ENSCAFT00000027468
,
ENSCAFG00000017333
VGNC
42596
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