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TP53 Tetramer [nucleoplasm]
Stable Identifier
R-CFA-3209194
Type
Complex
Species
Canis familiaris
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
ATM phosphorylates TP53 at S15 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
MDM2 binds TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
MDM2 ubiquitinates TP53 (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA damage checkpoint (Canis familiaris)
ATR phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular Senescence (Canis familiaris)
DNA Damage/Telomere Stress Induced Senescence (Canis familiaris)
ATM phosphorylates TP53 at S15 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Oncogene Induced Senescence (Canis familiaris)
MDM2 ubiquitinates TP53 (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Oxidative Stress Induced Senescence (Canis familiaris)
MDM2 ubiquitinates TP53 (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
ATM phosphorylates TP53 at S15 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Association with Co-factors (Canis familiaris)
BANP binds TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53:BANP [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Regulation of TP53 Activity through Methylation (Canis familiaris)
EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Regulation of TP53 Activity through Phosphorylation (Canis familiaris)
AMPK phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
ATM phosphorylates TP53 at S15 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
ATR phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
AURKA phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
CDK2 phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
CDK5 phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
NUAK1 phosphorylates TP53 (Canis familiaris)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
STK11 (LKB1) phosphorylates NUAK1 (Canis familiaris)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TAF1 phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 binds HIPK1 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 Tetramer:HIPK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 binds STK11 and NUAK1 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53RK phosphorylates TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
MDM2 binds TP53 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
MDM2 ubiquitinates TP53 (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Regulation of TP53 Expression (Canis familiaris)
TP53 forms homotetramers (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Transcriptional regulation by RUNX3 (Canis familiaris)
RUNX3 regulates CDKN1A transcription (Canis familiaris)
RUNX3 binds TP53 (Canis familiaris)
RUNX3:TP53 tetramer [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
PKR-mediated signaling (Canis familiaris)
p-PKR dimer phosphorylates TP53 tetramer (Canis familiaris)
TP53 Tetramer [nucleoplasm] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 4
TP53 [nucleoplasm]
(Canis familiaris)
Participates
as an input of
RUNX3 binds TP53 (Canis familiaris)
EHMT1:EHMT2 dimethylates TP53 (Canis familiaris)
p-PKR dimer phosphorylates TP53 tetramer (Canis familiaris)
BANP binds TP53 (Canis familiaris)
AURKA phosphorylates TP53 (Canis familiaris)
TP53 binds STK11 and NUAK1 (Canis familiaris)
CDK5 phosphorylates TP53 (Canis familiaris)
CDK2 phosphorylates TP53 (Canis familiaris)
TP53 binds HIPK1 (Canis familiaris)
TAF1 phosphorylates TP53 (Canis familiaris)
MDM2 binds TP53 (Canis familiaris)
AMPK phosphorylates TP53 (Canis familiaris)
TP53RK phosphorylates TP53 (Canis familiaris)
ATM phosphorylates TP53 at S15 (Canis familiaris)
ATR phosphorylates TP53 (Canis familiaris)
as a component of
RUNX3:TP53 tetramer [nucleoplasm] (Canis familiaris)
TP53:BANP [nucleoplasm] (Canis familiaris)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Canis familiaris)
TP53 Tetramer:HIPK1 [nucleoplasm] (Canis familiaris)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Canis familiaris)
as an output of
USP7 deubiquitinates TP53 and counteracts MDM2 (Canis familiaris)
TP53 forms homotetramers (Canis familiaris)
Inferred From
TP53 Tetramer [nucleoplasm]
(Homo sapiens)
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