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LEF1 [nucleoplasm]
Stable Identifier
R-CFA-3214972
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
LEF1, A0A8I3Q7N7
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by VENTX (Canis familiaris)
VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1 (Canis familiaris)
CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
VENTX:TCF4,LEF1:CCND1 Gene [nucleoplasm] (Canis familiaris)
TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Transcriptional regulation by RUNX3 (Canis familiaris)
RUNX3 regulates WNT signaling (Canis familiaris)
RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Canis familiaris)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
NLK phosphorylates TCF/LEF (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
Repression of WNT target genes (Canis familiaris)
TLE tetramers bind TCF/LEF at WNT promoters (Canis familiaris)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Canis familiaris)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Deactivation of the beta-catenin transactivating complex (Canis familiaris)
TCF:Beta-catenin binds SOX proteins (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Formation of the beta-catenin:TCF transactivating complex (Canis familiaris)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Beta-catenin recruits CBP/p300 (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Beta-catenin recruits CDC73 and LEO1 (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Beta-catenin recruits SMARCA4 (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Beta-catenin recruits TRRAP/KAT5 HAT components (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Beta-catenin:TCF associates with BCL9 and PYGO (Canis familiaris)
TCF/LEF:CTNNB1 [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
Recruitment of SET1 methyltransferase complex (Canis familiaris)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
LEF1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q7N7
Gene Names
LEF1
Reference Genes
ENSEMBL:ENSCAFG00845029249.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029249.1 LEF1
Other Identifiers
478507
CfaAffx.17535.1.S1_s_at
CfaAffx.17544.1.S1_at
GO:0000122
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001222
GO:0001227
GO:0001228
GO:0001569
GO:0001649
GO:0001756
GO:0001837
GO:0001944
GO:0002040
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005634
GO:0005667
GO:0005737
GO:0006310
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007155
GO:0008013
GO:0008301
GO:0010628
GO:0010718
GO:0012501
GO:0016020
GO:0016055
GO:0021542
GO:0021766
GO:0021861
GO:0021873
GO:0021943
GO:0022407
GO:0023052
GO:0030111
GO:0030154
GO:0030177
GO:0030223
GO:0030326
GO:0030331
GO:0030335
GO:0030509
GO:0030854
GO:0030879
GO:0032696
GO:0032713
GO:0032714
GO:0032993
GO:0033153
GO:0042100
GO:0042393
GO:0042475
GO:0042826
GO:0043066
GO:0043226
GO:0043565
GO:0043586
GO:0043923
GO:0045063
GO:0045295
GO:0045588
GO:0045843
GO:0045892
GO:0045893
GO:0045944
GO:0046632
GO:0048341
GO:0048468
GO:0048856
GO:0048870
GO:0050877
GO:0050909
GO:0060033
GO:0060070
GO:0060325
GO:0060326
GO:0060561
GO:0060710
GO:0061153
GO:0062009
GO:0070016
GO:0070742
GO:0071168
GO:0071345
GO:0071353
GO:0071864
GO:0071866
GO:0090575
GO:0098772
GO:0140110
GO:0140416
GO:1901331
GO:1902262
GO:1902732
GO:1904019
GO:1990837
GO:1990907
Participates
as a member of
TCF/LEF [nucleoplasm] (Canis familiaris)
TCF/LEF [nucleoplasm] (Canis familiaris)
TCF7L2,LEF1 [nucleoplasm] (Canis familiaris)
as a candidate of
TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Canis familiaris)
TCF7L1/TCF7L2/LEF1 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
phospho-LEF1 [nucleoplasm]
Inferred From
LEF1 [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000138795
Ensembl
ENSCAFT00845051755
,
ENSCAFP00845040605
,
ENSCAFG00845029249
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