Reactome | TAS2R3 [plasma membrane]

TAS2R3 [plasma membrane]

Stable Identifier

R-CFA-3299621

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

TAS2R3, Q2ABD8

Locations in the PathwayBrowser

Expand all

Sensory Perception (Canis familiaris)

- Sensory perception of taste (Canis familiaris)
  - Sensory perception of sweet, bitter, and umami (glutamate) taste (Canis familiaris)
    - Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)
      - TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Canis familiaris)
        
        TAS2R (non-orphan) [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
      - TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Canis familiaris)
        
        TAS2R (non-orphan):ligand [plasma membrane] (Canis familiaris)
        
        TAS2R3:ligand [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
      - T2Rs bind bitter-tasting compounds (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R3 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q2ABD8

Gene Names

TAS2R3

Reference Genes

BioGPS Gene:100271736 TAS2R3

ENSEMBL:ENSCAFG00845030932.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030932.1 TAS2R3

KEGG Gene (Canis lupus familiaris):100271736 TAS2R3

Monarch:100271736 TAS2R3

NCBI Gene:100271736 TAS2R3

Reference Transcript

RefSeq:NM_001145499.1 TAS2R3

Other Identifiers

100271736

GO:0001580

GO:0004930

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

Participates

as a member of

as a component of

TAS2R3:ligand [plasma membrane] (Canis familiaris)

Inferred From

TAS2R3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001138971.1

OpenTargets

ENSG00000127362

Ensembl

ENSCAFG00845030932, ENSCAFP00845043228, ENSCAFT00845054978

VGNC

47116