Reactome | CLTC [cytosol]

CLTC [cytosol]

Stable Identifier

R-CFA-350824

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

CLTC-1, A0A8I3PQE6

Locations in the PathwayBrowser

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Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - clathrin:HSPA8:ADP [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        Clathrin-coated vesicle [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Recruitment of AP-2 complex and clathrin (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - SNX9 recruits components of the actin polymerizing machinery (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        clathrin triskelion [cytosol] (Canis familiaris)
        
        Clathrin heavy chain [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
  - trans-Golgi Network Vesicle Budding (Canis familiaris)
    - Golgi Associated Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Coat Assembly (Canis familiaris)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - trans-Golgi Network Derived Vesicle Uncoating (Canis familiaris)
        
        Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - trans-Golgi Network Vesicle Scission (Canis familiaris)
        
        Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [cytoplasmic vesicle membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
    - Lysosome Vesicle Biogenesis (Canis familiaris)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - trans-Golgi Network Lysosomal Vesicle Scission (Canis familiaris)
        
        Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex [lysosomal membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
      - trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)
        
        Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Canis familiaris)
        
        Clathrin Triskelion [cytosol] (Canis familiaris)
        
        CLTC [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PQE6

Gene Names

CLTC

Reference Genes

BioGPS Gene:480578 CLTC

ENSEMBL:ENSCAFG00845025273.1

KEGG:cfa:480578 CLTC

Monarch:480578 CLTC

NCBI Gene:480578 CLTC

UCSC:A0A8I3PQE6 CLTC

Reference Transcript

RefSeq:XM_005624748.2 CLTC

Other Identifiers

CfaAffx.27024.1.S1_s_at

GO:0000278

GO:0003723

GO:0003725

GO:0005198

GO:0005764

GO:0005768

GO:0005773

GO:0005819

GO:0005829

GO:0005905

GO:0006886

GO:0006898

GO:0016192

GO:0030118

GO:0030130

GO:0030132

GO:0030136

GO:0030659

GO:0031410

GO:0031623

GO:0032051

GO:0032991

GO:0033572

GO:0042147

GO:0043226

GO:0045334

GO:0048268

GO:0050750

GO:0060236

GO:0065003

GO:0070062

GO:0071439

GO:0072583

GO:0072686

GO:0097718

GO:0150093

GO:1900126

GO:1903077

GO:1990381

GO:1990498

Participates

as a member of

Clathrin heavy chain [cytosol] (Canis familiaris)

as a candidate of

as a component of

Clathrin Triskelion [cytosol] (Canis familiaris)

Other forms of this molecule

CLTC [trans-Golgi network membrane]

CLTC [endolysosome membrane]

CLTC [clathrin-coated endocytic vesicle membrane]

CLTC [lysosomal membrane]

CLTC [plasma membrane]

Inferred From

CLTC [cytosol] (Homo sapiens)

CLTC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005624805.1

ENSEMBL

ENSCAFT00845045118, ENSCAFP00845035373

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