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DOCK1 [cytosol]
Stable Identifier
R-CFA-372654
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
F1P803
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Activation of Cdc42 (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Activation of Rac1 (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RhoGTPase GEF's recruited to DCC (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Factors involved in megakaryocyte development and platelet production (Canis familiaris)
DOCKs bind to RhoGEFs (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Phosphorylated PXN recruits the CRK complex (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
DOCK180:ELMO binds CRK (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 GEFs activate RAC2 (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RHOG GTPase cycle (Canis familiaris)
RHOG binds effectors at the plasma membrane (Canis familiaris)
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Canis familiaris)
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:F1P803
Reference Genes
ENSEMBL:ENSCAFG00000013062
Participates
as a candidate of
RAC2 GEFs [cytosol] (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
as a member of
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
DOCK1,TRIO [cytosol] (Canis familiaris)
as a component of
DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
Inferred From
DOCK1 [cytosol]
(Homo sapiens)
Cross References
VGNC
40043
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